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Use of olaparib in patients with advanced gastric cancer.

作者信息

Mo Miao, Yang Jianing, Zhu Xiaodong, Zhu Ji

机构信息

Department of Cancer Prevention, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

出版信息

Lancet Oncol. 2018 Feb;19(2):e75. doi: 10.1016/S1470-2045(18)30023-8.

DOI:10.1016/S1470-2045(18)30023-8
PMID:29413476
Abstract
摘要

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Use of olaparib in patients with advanced gastric cancer.奥拉帕利在晚期胃癌患者中的应用。
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Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trial.奥拉帕利联合紫杉醇治疗一线治疗后进展的晚期胃癌患者(GOLD):一项双盲、随机、安慰剂对照、III 期临床试验。
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Randomized, Double-Blind Phase II Trial With Prospective Classification by ATM Protein Level to Evaluate the Efficacy and Tolerability of Olaparib Plus Paclitaxel in Patients With Recurrent or Metastatic Gastric Cancer.随机、双盲 II 期临床试验,前瞻性按 ATM 蛋白水平分类,以评估奥拉帕利联合紫杉醇治疗复发性或转移性胃癌患者的疗效和耐受性。
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Use of olaparib in patients with advanced gastric cancer - Authors' reply.奥拉帕利在晚期胃癌患者中的应用——作者回复
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Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.奥拉帕利单药疗法在晚期乳腺癌、卵巢癌或输卵管癌患者中与卡铂和紫杉醇联合使用后的长期安全性及抗肿瘤活性
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Targeted therapies: SOLO2 confirms olaparib maintenance in ovarian cancer.靶向治疗:SOLO2试验证实奥拉帕利可用于卵巢癌的维持治疗。
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Missing a GOLDen opportunity in gastric cancer.错失胃癌治疗的绝佳时机。
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[Olaparib potentiates the antitumor effect of Taxol on 4T1 breast cancer].奥拉帕尼增强紫杉醇对4T1乳腺癌的抗肿瘤作用
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A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial.一项针对BRCA1或BRCA2突变的HER2阴性晚期乳腺癌一线治疗的I期试验,随后进行两个周期卡铂-奥拉帕利联合治疗,然后奥拉帕利单药治疗与卡培他滨对比的随机II期试验(REVIVAL):一项随机对照试验的研究方案。
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Therapeutic Targeting of DNA Damage Repair in the Era of Precision Oncology and Immune Checkpoint Inhibitors.精准肿瘤学和免疫检查点抑制剂时代的DNA损伤修复治疗靶点
J Immunother Precis Oncol. 2022 Dec 2;6(1):31-49. doi: 10.36401/JIPO-22-15. eCollection 2023 Feb.
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Gastric cancer: a comprehensive review of current and future treatment strategies.胃癌:当前和未来治疗策略的综合综述。
Cancer Metastasis Rev. 2020 Dec;39(4):1179-1203. doi: 10.1007/s10555-020-09925-3. Epub 2020 Sep 7.
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State-of-the-art strategies for targeting the DNA damage response in cancer.
针对癌症中 DNA 损伤反应的最新策略。
Nat Rev Clin Oncol. 2019 Feb;16(2):81-104. doi: 10.1038/s41571-018-0114-z.