Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russia; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Preparations, Moscow, Russia.
Institute of Molecular Medicine, Sechenov University, Moscow, Russia.
Infect Genet Evol. 2018 Apr;59:23-27. doi: 10.1016/j.meegid.2018.01.016. Epub 2018 Feb 4.
Phylodynamics of Crimean Congo Hemorrhagic fever virus (CCHFV) genotype V in South Russia was analyzed using 244 partial (452-571 nt) sequences in all three genomic segments and 38 complete genomic sequences. Despite increased number of sequences, the Russian lineage of the European genotype V (commonly termed GtVa) was distinct from GtV isolates from Turkey and the Balkan countries. No geographic pattern was observed in phylogenetic subgrouping of CCHFV within South Russia. Identical isolates could be found at distant locations spaced by hundreds of kilometers, while relatively divergent viruses circulated in the same region. Full genome analysis indicated that reassortment events within GtVa occurred every few decades (median half-life of a non-reassortant node 30-40 years) and involved M and S segments. Therefore, in South Russia CCHFV represents a highly dynamic population of frequently reassorting viruses.
采用三种基因组片段的 244 个部分（452-571nt）序列和 38 个全基因组序列对俄罗斯南部克里米亚-刚果出血热病毒（CCHFV）基因型 V 的系统发生进行了分析。尽管序列数量有所增加，但欧洲基因型 V（通常称为 GtVa）的俄罗斯谱系与来自土耳其和巴尔干国家的 GtV 分离株明显不同。在俄罗斯南部，CCHFV 的系统发育亚群中没有观察到地理模式。在相隔数百公里的遥远地点可能会发现相同的分离株，而在同一地区则存在相对差异较大的病毒。全基因组分析表明，GtVa 内的重配事件每几十年发生一次（非重配节点的中位数半衰期为 30-40 年），并涉及 M 和 S 片段。因此，在俄罗斯南部，CCHFV 代表了一种经常发生重配的高动态病毒种群。
