Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email:
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Annu Rev Med. 2018 Jan 29;69:97-111. doi: 10.1146/annurev-med-041316-090622.
There is growing awareness of the overlap between oncologic and cardiovascular (CV) diseases, including a wide range of CV effects of anticancer therapies. As novel anticancer therapeutics become available and cancer survival outcomes improve, the CV implications of cancer therapy become increasingly important. In addition to outlining the CV effects of commonly used cancer therapies and their consequences for long-term survivorship, this review highlights the recent efforts to improve the risk prediction and prevention of CV toxicity through the evaluation of sensitive measures for early toxicity detection and the implementation of cardioprotective strategies.
人们越来越意识到肿瘤学和心血管（CV）疾病之间存在重叠，包括抗癌疗法对 CV 的广泛影响。随着新型抗癌疗法的出现和癌症生存率的提高，癌症治疗的 CV 影响变得越来越重要。除了概述常用癌症疗法的 CV 效应及其对长期生存的影响外，本综述还强调了通过评估早期毒性检测的敏感指标和实施心脏保护策略来提高 CV 毒性风险预测和预防的最新努力。
