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肿瘤心脏病学:了解心脏毒性以指导以患者为中心的影像检查。

Cardio-oncology: Understanding cardiotoxicity to guide patient focused imaging.

机构信息

Warren Alpert Medical School of Brown University, 593 Eddy Street, APC737, Providence, RI, 02903, USA.

出版信息

J Nucl Cardiol. 2018 Dec;25(6):2159-2167. doi: 10.1007/s12350-018-01470-5. Epub 2018 Nov 15.

Abstract

Current cancer therapy has led to tremendous improvements in outcomes. These therapies rely both on established therapies, such as anthracyclines and radiation, and molecularly-targeted therapies, such as tyrosine kinase inhibitors and immune modulators. Integrative care for patients with cancer must consider the potential effects of these therapies on a variety of organ systems, including the cardiovascular system. As a result, specialties such as cardio-oncology have developed to identify these effects, determine how to best monitor for these effects, and how to treat and ultimately prevent these effects while allowing the patient to receive the therapy they require for their cancer. This review provides a basis for understanding the cardiovascular effects of cancer therapies so that the most appropriate imaging modality may be selected to prevent and treat these effects.

摘要

目前的癌症治疗在疗效上取得了巨大的进步。这些疗法既依赖于已确立的疗法,如蒽环类药物和放疗,也依赖于分子靶向疗法,如酪氨酸激酶抑制剂和免疫调节剂。癌症患者的综合治疗必须考虑这些疗法对包括心血管系统在内的各种器官系统的潜在影响。因此,已经发展出了肿瘤心脏病学等专业学科,以确定这些影响,确定如何最好地监测这些影响,以及如何在允许患者接受癌症治疗的同时治疗和最终预防这些影响。本文综述了癌症治疗的心血管影响,以便选择最合适的成像方式来预防和治疗这些影响。

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