核输入蛋白在癌症中的作用。
Karyopherins in cancer.
机构信息
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Curr Opin Cell Biol. 2018 Jun;52:30-42. doi: 10.1016/j.ceb.2018.01.006. Epub 2018 Feb 4.
Abstract
Malfunction of nuclear-cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells. In addition to their nuclear transport functions in interphase, Karyopherin nuclear transport receptors also have important roles in mitosis and chromosomal integrity. Therefore, alterations in the expressions or regular functions of Karyopherins may have substantial effects on the course and outcome of diseases.
摘要
核质运输功能障碍与许多疾病有关，包括癌症。核转运的缺陷导致肿瘤抑制因子、原癌基因和其他大分子的生理水平和时空位置发生变化，进而影响癌细胞的癌变过程和药物敏感性。除了在间期的核转运功能外，核转运受体还在有丝分裂和染色体完整性中发挥重要作用。因此，核转运蛋白的表达或正常功能的改变可能对疾病的过程和结果产生重大影响。
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