Piccolo Domenico, Kostaki Dimitra
Italian Association Outpatient Dermatologists, 00177 Rome, Italy.
Skin Center, Dermo-Aesthetic Lasers Centers, 67051 Avezzano, Italy.
Biomedicines. 2018 Feb 7;6(1):18. doi: 10.3390/biomedicines6010018.
Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC). We herein report our observational findings in a cohort of patients with a diagnosis of AK, sBCC, and BD that is treated with MAL-PDT using IPL, as well as we review published data on the use of IPL-PDT in NMSC.
外用5-氨基酮戊酸（ALA）或甲基氨基酮戊酸（MAL）的光动力疗法（PDT）已被证明是治疗光化性角化病（AK）、鲍恩病（BD）和浅表基底细胞癌（sBCC）的一种高效保守方法。传统上，PDT与广谱连续波光源（如红光或蓝光）联合使用。最近，强脉冲光（IPL）设备已被研究作为PDT的替代光源用于治疗非黑素瘤皮肤癌（NMSC）。我们在此报告了一组诊断为AK、sBCC和BD的患者使用IPL进行MAL-PDT治疗后的观察结果，并回顾了已发表的关于IPL-PDT在NMSC中应用的数据。
