Atlas S A, Kleinert H D, Camargo M J, Volpe M, Laragh J H, Lewicki J A, Maack T
J Clin Hypertens. 1985 Jun;1(2):187-98.
Atrial natriuretic factor (ANF) is a recently discovered peptide present in secretory granules specifically found in atrial muscle cells. Multiple structurally related peptides have been isolated from atrial tissues, all of which are derived from a common 152-amino-acid precursor. ANF induces profound natriuresis and diuresis in experimental animals and also causes relaxation of precontracted vascular smooth muscle. ANF has striking renal hemodynamic actions (most consistently an increased glomerular filtration rate), which probably explain its natriuretic effects. ANF also can inhibit renin secretion in vivo and causes direct inhibition of basal and stimulated aldosterone production. It lowers arterial blood pressure, probably reflecting in part its vasorelaxant actions, and this effect is particularly marked in renin-dependent (and possibly other vasoconstricted) models of hypertension. Although the exact structure and regulation of the presumed circulating form(s) of ANF remain to be clarified, available information suggests that it may be a new, previously unrecognized factor in the regulation of fluid volume and renal and cardiovascular function.
心房利钠因子（ANF）是一种最近发现的肽，存在于心房肌细胞特有的分泌颗粒中。已从心房组织中分离出多种结构相关的肽，它们均来源于一个共同的152个氨基酸的前体。ANF在实验动物中可引起显著的利钠和利尿作用，还可使预收缩的血管平滑肌舒张。ANF具有显著的肾血流动力学作用（最一致的是肾小球滤过率增加），这可能解释了其利钠作用。ANF在体内还可抑制肾素分泌，并直接抑制基础和刺激状态下的醛固酮生成。它可降低动脉血压，这可能部分反映了其血管舒张作用，且这种作用在肾素依赖性（可能还有其他血管收缩性）高血压模型中尤为明显。尽管ANF假定的循环形式的确切结构和调节仍有待阐明，但现有信息表明它可能是调节体液容量以及肾和心血管功能的一种新的、以前未被认识的因子。
