Patil Yogita, Bagade Suyog, Patil Nilesh, Jadhav Nalini
Department of Anaesthesia, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.
J Anaesthesiol Clin Pharmacol. 2017 Oct-Dec;33(4):524-528. doi: 10.4103/joacp.JOACP_61_16.
Desflurane and sevoflurane are inhalational anesthetics which provide stable intraoperative hemodynamics and rapid emergence from anesthesia. Dexmedetomidine is an α2-agonist with sedative and hypnotic effects. We compared recovery following anesthesia with a combination of a continuous intravenous infusion of dexmedetomidine and desflurane or sevoflurane in cases of spine surgeries because no such data are available from India.
It was a single-blind, prospective, randomized study. After institutional ethics committee approval, patients were randomly allocated to one of the two groups of fifty patients each. Group D received desflurane and Group S received sevoflurane, along with dexmedetomidine 0.5 μg/kg/h IV infusion for maintenance of anesthesia.
Extubation time (ET) in Group D was shorter by 4.2 min than in Group S (10.1 ± 2.2 and 14.2 ± 1.3; = 0.004). Postoperative recovery, postoperative analgesic, and antiemetic requirement between the groups were comparable The mean dial setting required to maintain the minimum alveolar concentration of 1 intraoperatively was 3.1 for desflurane and 0.7 for sevoflurane.
地氟烷和七氟烷是吸入性麻醉剂，可提供稳定的术中血流动力学并使患者迅速从麻醉中苏醒。右美托咪定是一种具有镇静和催眠作用的α2受体激动剂。由于印度尚无此类数据，我们比较了在脊柱手术中持续静脉输注右美托咪定与地氟烷或七氟烷联合麻醉后的恢复情况。
这是一项单盲、前瞻性、随机研究。经机构伦理委员会批准后，患者被随机分为两组，每组50例。D组接受地氟烷，S组接受七氟烷，同时静脉输注右美托咪定0.5μg/（kg·h）以维持麻醉。
D组的拔管时间（ET）比S组短4.2分钟（分别为10.1±2.2和14.2±1.3；P = 0.004）。两组之间的术后恢复、术后镇痛和止吐需求相当。术中维持最低肺泡浓度为1时，地氟烷所需的平均刻度设置为3.1，七氟烷为0.7。
