A cross-sectional study of inpatients with late stage of dementia in Southeast China and the associations between biochemical parameters and apolipoprotein E genotypes.

BACKGROUND

The purpose of this study was to analyze the disease distribution of patients in the late stage of dementia through a cross-sectional investigation and to clarify the association between apolipoprotein E () genotypes and the serum levels of total cholesterol, total triglycerides, and blood glucose in the late-stage Alzheimer's disease (AD) patients.

METHODS

Patients who were in the late stage of dementia in a mental health center were enrolled in this study. A broad battery of neuropsychological tests and neuroimaging was applied to make the diagnosis. The genotype was determined by the multiplex amplification refractory mutation system polymerase chain reaction. The association between genotype and the blood level of biochemical parameters was studied.

RESULTS

A total of 155 patients were enrolled in this study. The majority of patients had AD (67.8%), followed by vascular dementia (15.5%), mixed dementia (9%), and others (7.7%). The allele frequency was significantly different in the different groups. The serum level of total cholesterol (TC) in carriers was higher than in non-carriers (<0.05). No statistically significant differences were found in the blood glucose and triglycerides (TG) levels between these two groups.

CONCLUSION

To our knowledge, this is the first paper to study the characteristics of late-stage dementia in hospital patients in Southeast China. We found that the disease distribution was quite consistent with previous prevalence studies. Moreover, we found that the serum level of TC was higher in carriers group. However, no association was found between the allele and serum levels of glucose, TC and TG in the late stage of AD.