Department of Neurology and Research Center of Neurology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou.
Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen.
Clin Interv Aging. 2018 Jan 26;13:159-163. doi: 10.2147/CIA.S150283. eCollection 2018.
The purpose of this study was to analyze the disease distribution of patients in the late stage of dementia through a cross-sectional investigation and to clarify the association between apolipoprotein E () genotypes and the serum levels of total cholesterol, total triglycerides, and blood glucose in the late-stage Alzheimer's disease (AD) patients.
Patients who were in the late stage of dementia in a mental health center were enrolled in this study. A broad battery of neuropsychological tests and neuroimaging was applied to make the diagnosis. The genotype was determined by the multiplex amplification refractory mutation system polymerase chain reaction. The association between genotype and the blood level of biochemical parameters was studied.
A total of 155 patients were enrolled in this study. The majority of patients had AD (67.8%), followed by vascular dementia (15.5%), mixed dementia (9%), and others (7.7%). The allele frequency was significantly different in the different groups. The serum level of total cholesterol (TC) in carriers was higher than in non-carriers (<0.05). No statistically significant differences were found in the blood glucose and triglycerides (TG) levels between these two groups.
To our knowledge, this is the first paper to study the characteristics of late-stage dementia in hospital patients in Southeast China. We found that the disease distribution was quite consistent with previous prevalence studies. Moreover, we found that the serum level of TC was higher in carriers group. However, no association was found between the allele and serum levels of glucose, TC and TG in the late stage of AD.
本研究通过横断面调查分析了痴呆晚期患者的疾病分布，并阐明了载脂蛋白 E（）基因型与晚期阿尔茨海默病（AD）患者血清总胆固醇、总甘油三酯和血糖水平之间的关系。
本研究纳入了精神卫生中心的痴呆晚期患者。应用广泛的神经心理学测试和神经影像学来做出诊断。通过多重扩增障碍突变系统聚合酶链反应确定基因型。研究基因型与生化参数血液水平之间的关联。
本研究共纳入 155 例患者。大多数患者为 AD（67.8%），其次为血管性痴呆（15.5%）、混合性痴呆（9%）和其他类型（7.7%）。不同组之间等位基因频率存在显著差异。载脂蛋白 E 携带者的血清总胆固醇（TC）水平高于非携带者（<0.05）。两组间血糖和甘油三酯（TG）水平无统计学差异。
据我们所知，这是第一篇研究中国东南部医院住院患者痴呆晚期特征的论文。我们发现疾病分布与以往的流行率研究非常一致。此外，我们发现载脂蛋白 E 携带者组的 TC 血清水平较高。然而，在 AD 晚期，等位基因与血清葡萄糖、TC 和 TG 水平之间没有关联。
