de Medeiros Sebastiao Freitas, Angelo Laura Camila Antunes, de Medeiros Matheus Antonio Souto, Banhara Camila Regis, Barbosa Bruna Barcelo, Yamamoto Marcia Marly Winck
Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiaba, MT, Brazil.
Tropical Institute of Reproductive Medicine, Cuiaba, MT, Brazil.
J Clin Med Res. 2018 Mar;10(3):260-267. doi: 10.14740/jocmr3325w. Epub 2018 Jan 26.
The aim of this study was to examine the role of C-peptide as a biological marker of cardiometabolic risk in polycystic ovary syndrome (PCOS).
This case-control study enrolled 385 PCOS patients and 240 normal cycling women. Anthropometric and clinical variables were taken at first visit. Fasting C-peptide, glucose, lipids, and hormone measurements were performed. Simple and multiple correlations between C-peptide and other variables associated with dysmetabolism and cardiovascular disease were examined.
C-peptide was well correlated with several anthropometric, metabolic, and endocrine parameters. In PCOS patients, stepwise multiple regression including C-peptide as the criterion variable and other predictors of cardiovascular disease risk provided a significant model in which the fasting C-peptide/glucose ratio, glucose, body weight, and free estrogen index (FEI) were retained (adjusted R = 0.988, F = 7.161, P = 0.008).
C-peptide levels alone or combined with C-peptide/glucose ratio, glucose, body weight, and FEI provided a significant model to identify PCOS patients with higher risk of future cardiometabolic diseases.
本研究旨在探讨C肽作为多囊卵巢综合征（PCOS）心脏代谢风险生物标志物的作用。
本病例对照研究纳入了385例PCOS患者和240例正常月经周期女性。首次就诊时测量人体测量学和临床变量。进行空腹C肽、血糖、血脂和激素检测。研究了C肽与其他与代谢紊乱和心血管疾病相关变量之间的简单和多重相关性。
C肽与多个身体测量、代谢和内分泌参数密切相关。在PCOS患者中，以C肽作为标准变量和其他心血管疾病风险预测因子的逐步多元回归得出了一个显著模型，其中保留了空腹C肽/血糖比值、血糖、体重和游离雌激素指数（FEI）（调整R = 0.988，F = 7.161，P = 0.008）。
单独的C肽水平或与C肽/血糖比值、血糖、体重和FEI相结合，为识别未来发生心脏代谢疾病风险较高的PCOS患者提供了一个显著模型。
