Du Lehui, Yu Wei, Dai Xiangkun, Zhao Nana, Huang Xiang, Tong Fang, Liu Fang, Huang Yurong, Ju Zhongjian, Yang Wei, Cong Xiaohu, Xie Chuanbin, Liu Xiaoliang, Liang Lanqing, Han Yanan, Qu Baolin
Department of Radiation Oncology, Chinese PLA General Hospital, Beijing 100853, China.
Oncotarget. 2017 Dec 5;9(1):958-968. doi: 10.18632/oncotarget.22982. eCollection 2018 Jan 2.
A total of 149 lung cancer patients were recruited to receive intensity modulated radiation therapy (IMRT). The association of developing radiation pneumonitis (RP) with genetic polymorphism was evaluated. The risks of four polymorphic sites in three DNA repair related genes (ERCC1, rs116615:T354C and rs3212986:C1516A; ERCC2, rs13181:A2251C; XRCC1, rs25487:A1196G) for developing grade ≥ 2 RP were assessed respectively. It was observed that ERCC1 T354C SNP had a significant effect on the development of grade ≥ 2 RP (CT/TT vs. CC, adjusted HR = 0.517, 95% CI, 0.285-0.939; adjusted 0.030). It is the first time demonstrating that CT/TT genotype of ERCC1 354 was significantly associated with lower RP risk after radio therapy.
总共招募了149例肺癌患者接受调强放射治疗（IMRT）。评估了放射性肺炎（RP）的发生与基因多态性之间的关联。分别评估了三个DNA修复相关基因（ERCC1，rs116615：T354C和rs3212986：C1516A；ERCC2，rs13181：A2251C；XRCC1，rs25487：A1196G）中四个多态性位点发生≥2级RP的风险。观察到ERCC1 T354C单核苷酸多态性对≥2级RP的发生有显著影响（CT/TT与CC相比，调整后的HR = 0.517，95%CI，0.285 - 0.939；调整后的P = 0.030）。这是首次证明ERCC1 354的CT/TT基因型与放疗后较低的RP风险显著相关。
