• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

跨凝胶蛋白/TNS1表达升高是人类结直肠癌的一种潜在生物标志物。

Elevated transgelin/TNS1 expression is a potential biomarker in human colorectal cancer.

作者信息

Zhou Huimin, Zhang Yiming, Wu Lihao, Xie Wenrui, Li Lan, Yuan Yu, Chen Yu, Lin Ying, He Xinxiang

机构信息

Department of Gastroenterology and Hepatology, The First Affiliated Hospital, School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, China.

Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Oncotarget. 2017 Dec 15;9(1):1107-1113. doi: 10.18632/oncotarget.23275. eCollection 2018 Jan 2.

DOI:10.18632/oncotarget.23275
PMID:29416680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5787423/
Abstract

Transgelin is an actin-binding protein that regulates cell motility and other important cellular functions. Previous studies have suggested that transgelin expression is associated with cancer development and progression, but its specific role in colorectal cancer (CRC) remains controversial. We analyzed expression of transgelin and its candidate downstream target, tensin 1 (TNS1), in CRC patients using the ONCOMINE, Protein Atlas, and OncoLnc databases. Transgelin and TNS1 mRNA and protein levels were higher in CRC patients and CRC cell lines than in normal tissues and cells. Survival analyses using the OncoLnc database revealed that elevated TAGLN/TNS1 levels were associated with a poor overall survival in CRC patients. Transgelin suppression using siRNA decreased TNS1 expression in CRC cells, demonstrating that transgelin induces the TNS1 expression. Importantly, suppression of transgelin or TNS1 using siRNA decreased proliferation and invasiveness of CRC cells. These results suggest that transgelin/TNS1 signaling promotes CRC cell proliferation and invasion, and that transgelin/TNS1 expression levels could potentially serve as a prognostic and therapeutic target in CRC patients.

摘要

凝溶胶蛋白是一种肌动蛋白结合蛋白，可调节细胞运动及其他重要的细胞功能。先前的研究表明，凝溶胶蛋白的表达与癌症的发生和发展有关，但其在结直肠癌（CRC）中的具体作用仍存在争议。我们使用ONCOMINE、蛋白质图谱和OncoLnc数据库分析了结直肠癌患者中凝溶胶蛋白及其候选下游靶点张力蛋白1（TNS1）的表达情况。结直肠癌患者和结直肠癌细胞系中凝溶胶蛋白和TNS1的mRNA及蛋白质水平高于正常组织和细胞。使用OncoLnc数据库进行的生存分析显示，TAGLN/TNS1水平升高与结直肠癌患者较差的总生存率相关。使用小干扰RNA（siRNA）抑制凝溶胶蛋白可降低结直肠癌细胞中TNS1的表达，表明凝溶胶蛋白可诱导TNS1表达。重要的是，使用siRNA抑制凝溶胶蛋白或TNS1可降低结直肠癌细胞的增殖和侵袭能力。这些结果表明，凝溶胶蛋白/TNS1信号传导促进结直肠癌细胞增殖和侵袭，且凝溶胶蛋白/TNS1表达水平可能作为结直肠癌患者的预后和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/4dc12bb4b771/oncotarget-09-1107-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/47d15dc00c31/oncotarget-09-1107-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/8e0288f22133/oncotarget-09-1107-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/9bdc8825c0d5/oncotarget-09-1107-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/4dc12bb4b771/oncotarget-09-1107-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/47d15dc00c31/oncotarget-09-1107-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/8e0288f22133/oncotarget-09-1107-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/9bdc8825c0d5/oncotarget-09-1107-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1d/5787423/4dc12bb4b771/oncotarget-09-1107-g004.jpg

相似文献

1
Elevated transgelin/TNS1 expression is a potential biomarker in human colorectal cancer.跨凝胶蛋白/TNS1表达升高是人类结直肠癌的一种潜在生物标志物。
Oncotarget. 2017 Dec 15;9(1):1107-1113. doi: 10.18632/oncotarget.23275. eCollection 2018 Jan 2.
2
Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.凝胶蛋白增加结直肠癌细胞在体内的转移潜能，并改变参与细胞运动的基因的表达。
BMC Cancer. 2016 Feb 4;16:55. doi: 10.1186/s12885-016-2105-8.
3
AKT and JNK Signaling Pathways Increase the Metastatic Potential of Colorectal Cancer Cells by Altering Transgelin Expression.AKT和JNK信号通路通过改变转胶蛋白表达增加结肠直肠癌细胞的转移潜能。
Dig Dis Sci. 2016 Apr;61(4):1091-7. doi: 10.1007/s10620-015-3985-1. Epub 2015 Dec 22.
4
Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer.前列腺癌中肌动蛋白相关蛋白转胶蛋白（SM22）的表达减少。
Cell Tissue Res. 2010 Feb;339(2):337-47. doi: 10.1007/s00441-009-0902-y. Epub 2009 Dec 11.
5
Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT.芹菜素通过降低 AKT 的磷酸化水平而上调转谷氨酰胺酶并抑制结直肠癌细胞的侵袭和迁移。
J Nutr Biochem. 2013 Oct;24(10):1766-75. doi: 10.1016/j.jnutbio.2013.03.006. Epub 2013 Jun 14.
6
Transgelin interacts with PARP1 in human colon cancer cells.在人结肠癌细胞中，凝溶胶蛋白与聚（ADP - 核糖）聚合酶1（PARP1）相互作用。
Cancer Cell Int. 2020 Aug 3;20:366. doi: 10.1186/s12935-020-01461-y. eCollection 2020.
7
Downregulation of transgelin blocks interleukin-8 utilization and suppresses vasculogenic mimicry in breast cancer cells.原肌球蛋白的下调阻断白细胞介素-8的利用并抑制乳腺癌细胞中的血管生成拟态。
Exp Biol Med (Maywood). 2017 Mar;242(6):573-583. doi: 10.1177/1535370216685435. Epub 2017 Jan 6.
8
RacGAP1 expression, increasing tumor malignant potential, as a predictive biomarker for lymph node metastasis and poor prognosis in colorectal cancer.RacGAP1表达增加肿瘤恶性潜能，可作为结直肠癌淋巴结转移和预后不良的预测生物标志物。
Carcinogenesis. 2015 Mar;36(3):346-54. doi: 10.1093/carcin/bgu327. Epub 2015 Jan 7.
9
Quantitative proteomics reveals that distant recurrence-associated protein R-Ras and Transgelin predict post-surgical survival in patients with Stage III colorectal cancer.定量蛋白质组学研究表明，远处复发相关蛋白R-Ras和转胶蛋白可预测III期结直肠癌患者的术后生存率。
Oncotarget. 2016 Jul 12;7(28):43868-43893. doi: 10.18632/oncotarget.9701.
10
Epigenetic silencing of NDRG2 promotes colorectal cancer proliferation and invasion.NDRG2的表观遗传沉默促进结直肠癌的增殖和侵袭。
J Gastroenterol Hepatol. 2016 Jan;31(1):164-71. doi: 10.1111/jgh.13068.

引用本文的文献

1
Tensins in Cancer: Integration of Their Domain Functions, Context-Dependent Regulation and Biomarker Potential.癌症中的张力蛋白：其结构域功能、上下文依赖性调控及生物标志物潜力的整合
Biology (Basel). 2025 Aug 14;14(8):1053. doi: 10.3390/biology14081053.
2
GFAT1 promotes the progression of hepatocellular carcinoma via enhancing the O-GlcNAcylation of VEZF1.GFAT1通过增强VEZF1的O-连接N-乙酰葡糖胺化促进肝细胞癌进展。
Cell Death Dis. 2025 Aug 26;16(1):647. doi: 10.1038/s41419-025-07975-5.
3
Construction of a Prognostic Model based on CSC-related Genes in Patients with Colorectal Cancer.

本文引用的文献

1
Downregulation of transgelin blocks interleukin-8 utilization and suppresses vasculogenic mimicry in breast cancer cells.原肌球蛋白的下调阻断白细胞介素-8的利用并抑制乳腺癌细胞中的血管生成拟态。
Exp Biol Med (Maywood). 2017 Mar;242(6):573-583. doi: 10.1177/1535370216685435. Epub 2017 Jan 6.
2
Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility.凝胶蛋白增加结直肠癌细胞在体内的转移潜能，并改变参与细胞运动的基因的表达。
BMC Cancer. 2016 Feb 4;16:55. doi: 10.1186/s12885-016-2105-8.
3
Cancer statistics, 2016.
基于结直肠癌患者CSC相关基因构建预后模型
J Cancer. 2025 Apr 13;16(7):2375-2387. doi: 10.7150/jca.108188. eCollection 2025.
4
The role of tensins in malignant neoplasms.张力蛋白在恶性肿瘤中的作用。
Arch Med Sci. 2021 Jan 26;19(5):1382-1397. doi: 10.5114/aoms/127085. eCollection 2023.
5
as Model System to Study Ras-Mediated Oncogenesis: The Case of the Tensin Family of Proteins.作为研究 Ras 介导的致癌作用的模型系统：以张力蛋白家族蛋白为例。
Genes (Basel). 2023 Jul 23;14(7):1502. doi: 10.3390/genes14071502.
6
Tensins in Kidney Function and Diseases.肾素在肾功能及疾病中的作用
Life (Basel). 2023 May 24;13(6):1244. doi: 10.3390/life13061244.
7
Whole Transcriptome Sequencing Reveals Cancer-Related, Prognostically Significant Transcripts and Tumor-Infiltrating Immunocytes in Mantle Cell Lymphoma.全转录组测序揭示套细胞淋巴瘤中与癌症相关、具有预后意义的转录本和肿瘤浸润免疫细胞。
Cells. 2022 Oct 27;11(21):3394. doi: 10.3390/cells11213394.
8
TNS1: Emerging Insights into Its Domain Function, Biological Roles, and Tumors.TNS1：对其结构域功能、生物学作用及肿瘤的新见解
Biology (Basel). 2022 Oct 26;11(11):1571. doi: 10.3390/biology11111571.
9
The progress of research into pseudophosphatases.磷酸酶拟似物研究进展。
Front Public Health. 2022 Aug 29;10:965631. doi: 10.3389/fpubh.2022.965631. eCollection 2022.
10
Dichotomous role of miR193b-3p in diabetic foot ulcers maintains inhibition of healing and suppression of tumor formation.miR193b-3p 在糖尿病足溃疡中的二分角色维持对愈合的抑制和肿瘤形成的抑制。
Sci Transl Med. 2022 May 11;14(644):eabg8397. doi: 10.1126/scitranslmed.abg8397.
癌症统计数据，2016 年。
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. doi: 10.3322/caac.21332. Epub 2016 Jan 7.
4
AKT and JNK Signaling Pathways Increase the Metastatic Potential of Colorectal Cancer Cells by Altering Transgelin Expression.AKT和JNK信号通路通过改变转胶蛋白表达增加结肠直肠癌细胞的转移潜能。
Dig Dis Sci. 2016 Apr;61(4):1091-7. doi: 10.1007/s10620-015-3985-1. Epub 2015 Dec 22.
5
Colorectal Cancer Mortality Characteristics and Predictions in China, 1991-2011.1991 - 2011年中国结直肠癌死亡率特征及预测
Asian Pac J Cancer Prev. 2015;16(17):7991-5. doi: 10.7314/apjcp.2015.16.17.7991.
6
[Burden of colorectal cancer in China].[中国结直肠癌负担]
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Jul;36(7):709-14.
7
Tumor vessel up-regulation of INSR revealed by single-cell expression analysis of the tyrosine kinome and phosphatome in human cancers.通过对人类癌症中酪氨酸激酶组和磷酸化蛋白质组的单细胞表达分析揭示肿瘤血管中胰岛素受体（INSR）的上调。
Am J Pathol. 2015 Jun;185(6):1600-9. doi: 10.1016/j.ajpath.2015.02.019. Epub 2015 Apr 10.
8
Transgelins, cytoskeletal proteins implicated in different aspects of cancer development.转胶蛋白，细胞骨架蛋白，涉及癌症发展的多个方面。
Expert Rev Proteomics. 2014 Apr;11(2):149-65. doi: 10.1586/14789450.2014.860358. Epub 2014 Jan 29.
9
Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer.微卫星稳定型结直肠癌常见局灶性染色体畸变中候选驱动基因的鉴定
PLoS One. 2013 Dec 18;8(12):e83859. doi: 10.1371/journal.pone.0083859. eCollection 2013.
10
Transgelin promotes migration and invasion of cancer stem cells.转胶蛋白促进癌症干细胞的迁移和侵袭。
J Proteome Res. 2010 Oct 1;9(10):5108-17. doi: 10.1021/pr100378z.