Shimono Joji, Miyoshi Hiroaki, Kato Takeharu, Sugio Takeshi, Miyawaki Kohta, Kamimura Tomohiko, Miyagishima Takuto, Eto Tetsuya, Imaizumi Yoshitaka, Kato Koji, Nagafuji Koji, Akashi Koichi, Seto Masao, Teshima Takanori, Ohshima Koichi
Department of Pathology, Kurume University, School of Medicine, Kurume, Japan.
Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Oncotarget. 2017 Dec 11;9(2):1717-1725. doi: 10.18632/oncotarget.23138. eCollection 2018 Jan 5.
Hepatitis C virus (HCV) is a single-stranded RNA virus that not only affects hepatocytes, by B cells as well. It is thought that HCV is involved in the onset of B-cell lymphoma. The clinicopathological characteristics of HCV-positive diffuse large B-cell lymphoma (DLBCL) and HCV-positive splenic marginal zone lymphoma (SMZL) are known, but there has been no report on HCV-positive follicular lymphoma (FL). In this study, the clinicopathological characteristics of HCV-positive FL were examined in 263 patients with FL who were classified into a HCV-positive group with HCV antibody and negative groups without one. The number of patients with HCV-positive FL and HCV-negative FL was 10 (3.8%) and 253 (96.2%), respectively. The patients with HCV-positive FL commonly had more than one region of lymphadenopathy, Ann Arbor stage III/IV, hemoglobin <120 g/l, elevated lactate dehydrogenase level, and high-risk categorization of Follicular Lymphoma International Prognostic Index (FLIPI) than in patients with HCV-negative FL. Overall survival and progression-free survival were poorer in patients with HCV-positive FL than in those with HCV-negative FL ( < 0.0001 and 0.006, respectively). Also, multivariate analysis revealed that positive HCV antibody was a poor prognostic factor of OS. In conclusion, HCV-positive FL has unique clinical features and may have a great impact on the overall survival of affected patients.
丙型肝炎病毒（HCV）是一种单链RNA病毒，不仅会影响肝细胞，还会影响B细胞。据认为，HCV与B细胞淋巴瘤的发病有关。HCV阳性弥漫性大B细胞淋巴瘤（DLBCL）和HCV阳性脾边缘区淋巴瘤（SMZL）的临床病理特征已为人所知，但尚无关于HCV阳性滤泡性淋巴瘤（FL）的报道。在本研究中，对263例FL患者进行了HCV阳性FL的临床病理特征检查，这些患者被分为有HCV抗体的HCV阳性组和无HCV抗体的阴性组。HCV阳性FL患者和HCV阴性FL患者的人数分别为10例（3.8%）和253例（96.2%）。与HCV阴性FL患者相比，HCV阳性FL患者通常有多个淋巴结肿大区域、Ann Arbor分期为III/IV期、血红蛋白<120 g/l、乳酸脱氢酶水平升高以及滤泡性淋巴瘤国际预后指数（FLIPI）高危分类。HCV阳性FL患者的总生存期和无进展生存期比HCV阴性FL患者差（分别为<0.0001和0.006）。此外，多变量分析显示，HCV抗体阳性是总生存期的不良预后因素。总之，HCV阳性FL具有独特的临床特征，可能对受影响患者的总生存期产生重大影响。
