Elias A N, Vaziri N D, Maksy M
Nephron. 1986;43(3):173-6. doi: 10.1159/000183825.
The effect of hemodialysis on the plasma concentration of beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) was studied in 11 patients with end-stage renal disease (ESRD). The plasma beta-EP/beta-LPH concentrations measured at 13.00 h were not significantly different in the patients compared to age-matched controls. Furthermore, hemodialysis produced no change in the plasma concentrations of beta-EP/beta-LPH. The elevated levels of beta-EP/LPH previously reported are most likely a reflection of the measurement of these peptides at a time of peak diurnal secretion compounded by a fall in the metabolic clearance rate of the endogenous opioids in ESRD. It remains to be established whether measurement of adronocorticotropic hormone or beta-EP/beta-LPH is more accurate an indicator of the integrity of the hypothalamic-pituitary-adrenal axis in patients with ESRD.
对11例终末期肾病（ESRD）患者研究了血液透析对β-内啡肽（β-EP）和β-促脂素（β-LPH）血浆浓度的影响。与年龄匹配的对照组相比，患者在13:00测得的血浆β-EP/β-LPH浓度无显著差异。此外，血液透析未使血浆β-EP/β-LPH浓度发生变化。先前报道的β-EP/LPH水平升高很可能反映了在昼夜分泌高峰时对这些肽的测量，同时还伴有ESRD患者内源性阿片类物质代谢清除率下降。对于ESRD患者，促肾上腺皮质激素或β-EP/β-LPH的测量能否更准确地反映下丘脑-垂体-肾上腺轴的完整性，仍有待确定。
