[慢性肾衰竭中的循环阿片肽：透析治疗的急性效应]
[Circulating opioid peptides in chronic renal failure: acute effect of dialysis treatment].
作者信息
Petraglia F, Facchinetti F, De Leo M, Parrini D, De Leo V, Verzetti G, De Luca S, Genazzani A R
出版信息
Boll Soc Ital Biol Sper. 1982 May 15;58(9):578-84.
In 14 patients affected by chronic renal failure (7 males and 7 females) it has been evaluated the secretion of beta LPH, beta EP, ACTH and Cortisol in basal conditions and immediately after a dialytic treatment. For beta LPH and beta EP measurements on each thawed plasma a silic acid extraction and a successive peptides separation by a Sephadex G-75 column chromatography preceeded the two specific RIAs. Basal beta LPH plasma levels resulted significantly higher than in normal controls, while that of beta EP, ACTH and Cortisol were in the normal range. The dialytic treatment was able to increase ACTH and Cortisol plasma levels, without to modified beta LPH and beta EP plasma levels.
在14例慢性肾衰竭患者（7例男性和7例女性）中，评估了基础状态下以及透析治疗后即刻β-促脂解素（β-LPH）、β-内啡肽（β-EP）、促肾上腺皮质激素（ACTH）和皮质醇的分泌情况。对于每次解冻血浆中β-LPH和β-EP的测量，在两种特异性放射免疫测定（RIA）之前，先进行硅酸萃取，然后通过葡聚糖凝胶G-75柱色谱法进行后续的肽分离。基础状态下β-LPH血浆水平显著高于正常对照组，而β-EP、ACTH和皮质醇的水平在正常范围内。透析治疗能够提高ACTH和皮质醇的血浆水平，但未改变β-LPH和β-EP的血浆水平。
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