Mokhtari Fatemeh, Gholami Maryam, Siadat Amir Hossein, Jafari-Koshki Tohid, Faghihi Gita, Nilforoushzadeh Mohammad Ali, Hosseini Sayed Mohsen, Abtahi-Naeini Bahareh
Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Biostatistics and Epidemiology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Res Pharm Pract. 2017 Oct-Dec;6(4):199-205. doi: 10.4103/jrpp.JRPP_17_29.
Acne vulgaris is a disease of pilosebaceous unit with multifactorial pathogenesis and threats patients' social functioning. There is a growing research to find faster, more effective, and easy to use treatments. The aim of this study is to evaluate the efficacy of benzoyl peroxide 5% (BP) with and without concomitant intense-pulsed light (IPL) therapy in mild-to-moderate acne vulgaris.
In this controlled trial, 58 eligible patients with mild-to-moderate acne and Fitzpatrick skin phototype III and IV were randomly allocated to two groups. All patients were asked to use a thin layer of BP every night. The IPL therapy was administered at the end of first, 2, and 3 months. Acne Global Severity Scale (AGSS), Acne Severity Index (ASI), and total lesion counting (TLC) along with patient satisfaction were recorded. Patients were also examined 1 month after the final therapeutic visit.
The IPL group showed greater reduction in AGSS ( < 0.001) and TLC ( = 0.005) than the control group. However, the difference in ASI was not significant ( = 0.12). Patients in IPL groups were more satisfied than control group ( < 0.001).
Adding IPL to BP can result better response to BP alone. In acne treatment, combination therapy such as IPL and other topical agents should be kept in mind.
寻常痤疮是一种毛囊皮脂腺疾病，其发病机制具有多因素性，会对患者的社交功能构成威胁。目前对于寻找更快、更有效且易于使用的治疗方法的研究越来越多。本研究的目的是评估5%过氧化苯甲酰（BP）单独使用以及联合强脉冲光（IPL）治疗对轻至中度寻常痤疮的疗效。
在这项对照试验中，58名符合条件的轻至中度痤疮患者以及Fitzpatrick皮肤光类型为III型和IV型的患者被随机分为两组。所有患者均被要求每晚使用薄层BP。IPL治疗在第1、2和3个月末进行。记录痤疮全球严重程度量表（AGSS）、痤疮严重程度指数（ASI）、总皮损计数（TLC）以及患者满意度。在最后一次治疗访视后1个月对患者进行检查。
IPL组在AGSS（<0.001）和TLC（=0.005）方面的降低幅度大于对照组。然而，ASI的差异不显著（=0.12）。IPL组患者比对照组更满意（<0.001）。
在BP治疗中添加IPL可产生比单独使用BP更好的反应。在痤疮治疗中，应考虑IPL与其他局部用药等联合治疗。
