Nakazato Y, Landing B H
Pediatr Pathol. 1986;5(1):55-63. doi: 10.3109/15513818609068848.
Four patients with Down syndrome and 3 age-matched control patients were studied by a microdissection technique to investigate the number of neurons in the ganglia of the deep submucous and Auerbach plexuses of the esophagus. The mean number of neurons per ganglion of the deep submucous plexus in Down patients was 69% of the control value, and the value for the Auerbach plexus was 75% of control number. These findings may explain esophageal dysfunction, common in Down syndrome, and support a proposal that a biochemical "signal" relating to chromosome 21 determines the number and sizes of certain cell types.
采用显微解剖技术对4例唐氏综合征患者和3例年龄匹配的对照患者进行研究，以调查食管深黏膜下神经丛和奥尔巴赫神经丛神经节中的神经元数量。唐氏患者深黏膜下神经丛每个神经节的平均神经元数量为对照值的69%，奥尔巴赫神经丛的值为对照数量的75%。这些发现可能解释了唐氏综合征中常见的食管功能障碍，并支持了一种观点，即与21号染色体相关的生化“信号”决定了某些细胞类型的数量和大小。
