Department of Endocrinology & Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai, 200072, China.
Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu Province, 211166, China.
Obes Surg. 2018 Jul;28(7):1960-1965. doi: 10.1007/s11695-018-3116-0.
The study was designed to examine changes of body fat distribution after laparoscopic sleeve gastrectomy (LSG) in obese male patients and to confirm whether these changes are correlated with increased testosterone.
A total of 30 obese male patients with body mass index (BMI) 30-45 kg/m were enrolled in this study. Data on demographic characteristics, anthropometry, metabolic parameters, and body fat distribution were collected at baseline and 6 months after LSG. Body fat distribution was assessed by dual-energy X-ray absorptiometry (DXA).
Six months after surgery, the BMI of participants (age 33.0 ± 9.5) decreased from 40.2 ± 5.2 to 30.8 ± 4.4 kg/m, total testosterone increased from 2.4 ± 1.2 to 4.5 ± 1.8 ng/mL, and the percentage of testosterone deficiency in these patients decreased from 82.7 to 23.1%. Fat mass was significantly decreased in all regions, but the loss of fat mass in the android region was more than that in any other body region. After adjusting age and the BMI, the changes in android FM% and gynoid FM% were significantly correlated with an increase in total testosterone concentration (R = 0.187, R = 0.282, respectively).
In obese male patients with BMI 30-45 kg/m, an increase of total testosterone correlated to the changes in android FM% and gynoid FM% at the sixth month after LSG surgery.
本研究旨在探讨腹腔镜袖状胃切除术（LSG）后肥胖男性患者体脂分布的变化，并确认这些变化是否与睾酮增加有关。
共纳入 30 名 BMI 为 30-45 kg/m 的肥胖男性患者。收集基线和 LSG 术后 6 个月时的人口统计学特征、人体测量学、代谢参数和体脂分布数据。通过双能 X 射线吸收法（DXA）评估体脂分布。
术后 6 个月时，参与者（年龄 33.0±9.5）的 BMI 从 40.2±5.2 降至 30.8±4.4 kg/m，总睾酮从 2.4±1.2 增至 4.5±1.8 ng/mL，且这些患者的睾酮缺乏比例从 82.7%降至 23.1%。所有部位的脂肪量均显著减少，但男性型肥胖区域的脂肪量减少量多于其他任何身体区域。调整年龄和 BMI 后，android FM%和女性型肥胖 FM%的变化与总睾酮浓度的增加呈显著相关（R=0.187，R=0.282）。
对于 BMI 为 30-45 kg/m 的肥胖男性患者，LSG 术后 6 个月时总睾酮的增加与 android FM%和女性型肥胖 FM%的变化相关。
