Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Int J Dermatol. 2018 Jun;57(6):635-641. doi: 10.1111/ijd.13873. Epub 2018 Feb 8.
Probiotic treatment of atopic dermatitis is widely studied with controversial results. The objective of this study is to review the efficacy of probiotics for the treatment of atopic dermatitis in infants. PubMed, Embase, and Cochrane Central Register of Controlled Trials databases, and reference lists were searched up to July 2017. Double-blinded randomized clinical trials were included. The primary outcome was the Scoring Atopic Dermatitis index. Subgroups analyses were conducted on probiotic species, treatment duration, participant age, and disease severity. Eight clinical trials (741 infants) were included in the quantitative synthesis. The overall pooled change in Scoring Atopic Dermatitis index (95% CI) in infants was -5.71 (-8.37, -3.04), P < 0.01. Subgroup analysis revealed that the effect was protective in moderate-to-severe patients -8.32 (-16.35, -0.28), with preparations containing Lactobacillus -5.76 (-9.21, -2.30). Probiotics for the treatment of infantile atopic dermatitis is beneficial.
益生菌治疗特应性皮炎的研究广泛，但结果存在争议。本研究旨在综述益生菌治疗婴儿特应性皮炎的疗效。检索了 PubMed、Embase 和 Cochrane 中央对照试验注册库以及参考文献列表，检索时间截至 2017 年 7 月。纳入双盲随机临床试验。主要结局指标为特应性皮炎评分指数。对益生菌种类、治疗持续时间、参与者年龄和疾病严重程度进行了亚组分析。纳入了 8 项临床试验（741 例婴儿）进行定量综合分析。婴儿特应性皮炎评分指数的总体变化（95%CI）为-5.71（-8.37，-3.04），P < 0.01。亚组分析显示，中重度患者的疗效具有保护作用-8.32（-16.35，-0.28），含乳杆菌的制剂-5.76（-9.21，-2.30）。益生菌治疗婴儿特应性皮炎有益。
