Department of Maternal Infantile and Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Int J Mol Sci. 2023 Jun 6;24(12):9781. doi: 10.3390/ijms24129781.
Cow's milk protein allergy (CMPA) is the most common food allergy (FA) in infancy, affecting approximately 2% of children under 4 years of age. According to recent studies, the increasing prevalence of FAs can be associated with changes in composition and function of gut microbiota or "dysbiosis". Gut microbiota regulation, mediated by probiotics, may modulate the systemic inflammatory and immune responses, influencing the development of allergies, with possible clinical benefits. This narrative review collects the actual evidence of probiotics' efficacy in the management of pediatric CMPA, with a specific focus on the molecular mechanisms of action. Most studies included in this review have shown a beneficial effect of probiotics in CMPA patients, especially in terms of achieving tolerance and improving symptoms.
牛奶蛋白过敏（CMPA）是婴儿期最常见的食物过敏（FA），影响约 4 岁以下儿童的 2%。根据最近的研究，FA 的患病率增加可能与肠道微生物群组成和功能的变化或“失调”有关。益生菌介导的肠道微生物群调节可能调节全身炎症和免疫反应，影响过敏的发展，并可能具有临床益处。本综述收集了益生菌在儿童 CMPA 管理中的实际疗效证据，特别关注作用的分子机制。本综述中纳入的大多数研究表明益生菌对 CMPA 患者有益，尤其是在实现耐受和改善症状方面。
