Eating Recovery Center, Denver, Denver, Colorado.
ACUTE, at Denver Health, Denver, Colorado.
Int J Eat Disord. 2018 Apr;51(4):305-313. doi: 10.1002/eat.22830. Epub 2018 Feb 8.
Eating disorders are associated with multiple medical complications. We report contemporary medical data, for newly admitted adult inpatient and residential level of care patients.
Medical records of a transdiagnostic sample of 1,026 patients, with eating disorders, were retrospectively reviewed for the presence of a broad array of medical complications at time of admission. The prevalence of physiologically relevant medical complications was assessed across major eating disorder categories.
Of the patients, 93.6% were female, and they had an average age of 28.1 (SD = 10.1, range 17-69). The average admission body mass index was 16.1 (SD = 2.3). The prevalence of abnormal laboratory values varied by eating disorder subtype. In patients with anorexia nervosa-restricting subtype, 51.4% had low prealbumin, 36.1% were leukopenic, 34.3% had osteoporosis, 30.0% vitamin D deficiency, 16.8% metabolic alkalosis, 16.0% had hyponatremia, 14.2% hypokalemia, and 7.1% hypoglycemia. These patients had normal average QTc intervals. In patients with anorexia nervosa-binge purging subtype, 42.4% had hypokalemia, 33.3% metabolic alkalosis, osteoporosis in 21.1%, and they had longer QTc intervals (433.9 ms, p < .001). Only 6.0% of patients with anorexia nervosa had hypophosphatemia. Patients with bulimia nervosa demonstrated hypokalemia in 26.2%, and metabolic alkalosis in 23.4%; the QTc interval was longer than in AN-R patients (437.9 ms, p < .001), but still in the normal range.
Numerous medical complications are associated with severe eating disorders. As the severity increases, the number of complications increase and are related to the presence or absence of purging behaviors.
饮食失调与多种医学并发症有关。我们报告了新入院的成年住院和住宅护理水平患者的当代医学数据。
对 1026 名饮食失调患者的跨诊断样本的医疗记录进行回顾性审查，以确定入院时是否存在广泛的医学并发症。评估了主要饮食失调类别中与生理相关的并发症的患病率。
患者中 93.6%为女性，平均年龄为 28.1（SD=10.1，范围为 17-69）。入院时的平均体重指数为 16.1（SD=2.3）。异常实验室值的患病率因饮食失调亚型而异。在神经性厌食症限制型亚组患者中，51.4%低白蛋白血症，36.1%白细胞减少症，34.3%骨质疏松症，30.0%维生素 D 缺乏症，16.8%代谢性碱中毒，16.0%低钠血症，14.2%低钾血症和 7.1%低血糖症。这些患者的平均 QTc 间隔正常。在神经性厌食症暴食-呕吐型亚组患者中，42.4%低钾血症，33.3%代谢性碱中毒，21.1%骨质疏松症，并且 QTc 间隔较长（433.9 ms，p<.001）。仅有 6.0%的神经性厌食症患者存在低磷血症。神经性贪食症患者中有 26.2%存在低钾血症，23.4%存在代谢性碱中毒；与 AN-R 患者相比，QTc 间隔更长（437.9 ms，p<.001），但仍在正常范围内。
严重的饮食失调与许多医学并发症有关。随着严重程度的增加，并发症的数量增加，并且与是否存在清除行为有关。
