State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Respirology. 2018 Jul;23(7):704-713. doi: 10.1111/resp.13258. Epub 2018 Feb 8.
No previous studies have examined differences in spirometry measurements among ethnic populations in China, and factors which may influence ethnic differences are unclear. Our study aimed to investigate whether forced expiratory volume in 1 s (FEV ) and forced vital capacity (FVC) differ among Han Chinese and other ethnic minorities in China.
We recruited 7137 individuals aged 35-70 years from four areas of China inhabited by ethnic minority groups between 2007 and 2009. We conducted spirometry tests for all available participants, and compared FEV and FVC among Uygur, Hui, Mongolian, Dai and Han Chinese ethnicities, using nonlinear multiplicative regression models.
A total of 2005 healthy never-smokers were enrolled in the analysis. For all ethnicities, spirometry values increased with height and decreased with age; FEV and FVC were consistently higher in males than in females. Compared with Han Chinese, FEV was 4.42% (95% CI: 2.11-6.78%) higher in Mongolians, 4.08% (95% CI: 1.33-6.76%) lower in Uygurs, 4.39% (95% CI: 1.33-7.35%) lower in Hui people and 4.72% (95% CI: 1.80-7.55%) lower in Dai people, after adjusted for potential confounders including height, age, sex and place of residence. We observed similar differences for FVC.
We detected significant differences in spirometry measurements among ethnic populations in China. Such differences cannot be fully explained by demographic, anthropometric or socioeconomic factors, but may also be attributed to genetic background as well as indoor and outdoor environmental exposures that need further investigation.
既往研究并未探讨中国不同民族人群肺功能测量值的差异，且影响民族差异的因素尚不清楚。本研究旨在探讨中国汉族人群与其他少数民族人群的 1 秒用力呼气容积（FEV ）和用力肺活量（FVC ）是否存在差异。
我们于 2007 年至 2009 年在我国四个少数民族聚居地区招募了年龄在 35-70 岁之间的 7137 名个体。我们对所有可评估的参与者进行了肺功能检查，并使用非线性乘法回归模型比较了维吾尔族、回族、蒙古族、傣族和汉族的 FEV 和 FVC 。
共纳入了 2005 名健康的从不吸烟者进行分析。所有民族的肺功能值均随身高的增加而增加，随年龄的增长而降低；男性的 FEV 和 FVC 始终高于女性。与汉族相比，蒙古族的 FEV 高 4.42%（95%可信区间：2.11-6.78%），维吾尔族低 4.08%（95%可信区间：1.33-6.76%），回族低 4.39%（95%可信区间：1.33-7.35%），傣族低 4.72%（95%可信区间：1.80-7.55%），这些差异在调整了包括身高、年龄、性别和居住地点等潜在混杂因素后仍然存在。我们观察到 FVC 也存在类似的差异。
我们在中国不同民族人群中发现了肺功能测量值的显著差异。这些差异不能完全用人口统计学、人体测量学或社会经济因素来解释，也可能与遗传背景以及室内外环境暴露有关，需要进一步研究。
