Xu Si-Qi, Dai Jia-Ping, Hu Xu-Qi
Department of Orthopaedics, the Second Hospital of Jiaxing, Jiaxing 314000, Zhejiang, China;
Zhongguo Gu Shang. 2017 May 25;30(5):481-483. doi: 10.3969/j.issn.1003-0034.2017.05.018.
The mechanism of degenerative intervertebral disc is very complex, which may be associated with multiple factors such as the mechanical stress force injury of intervertebral disc, nutritional deficiency, inflammatory stimulation, etc. Recently, many studies detected propionibacterium acnes(P. acnes) in degenerative intervertebral disc and supposed P. acnes was associated with degenerative intervertebral disc. Here, the papers related to P. acnes and degenerative intervertebral disc were reviewed. Further, we deduced the approach of P. acnes enterring into the intervertebral disc as well as the mechanism of P. acnes aggravating the disc degeneration. These may provide suggestions for treating degenerative intervertebral disc.
椎间盘退变的机制非常复杂，可能与多种因素有关，如椎间盘的机械应力损伤、营养缺乏、炎症刺激等。最近，许多研究在退变的椎间盘中检测到痤疮丙酸杆菌（P. acnes），并认为P. acnes与椎间盘退变有关。在此，对与P. acnes和椎间盘退变相关的文献进行综述。此外，我们推断了P. acnes进入椎间盘的途径以及P. acnes加重椎间盘退变的机制。这些可能为治疗椎间盘退变提供建议。
