Pryjma J, Flad H D, Gruber M, Ernst M
Scand J Immunol. 1986 Jul;24(1):21-8. doi: 10.1111/j.1365-3083.1986.tb02065.x.
Human peripheral blood monocyte subsets with and without Fc receptor for human IgG are known to suppress (FcR+) and enhance (FcR-) pokeweed mitogen-induced polyclonal immunoglobulin synthesis in vitro. The ability of these subsets to modulate immunoglobulin production in the presence or absence of OKT8+ T cells and under conditions where suppressor T-cell activation was blocked by irradiation or mitomycin C was studied. It was shown that, regardless of the presence or absence of suppressor T cells, FcR+ monocytes can suppress immunoglobulin production if their number in culture exceeds 20%. However, at lower numbers this monocyte subset was suppressive only when suppressor T cells were activated. The suppressor T-cell activation was shown to be independent of the predominant presence of the FcR+ or FcR- monocyte subset. Moreover, the enhancing effect of FcR- monocytes was not caused by their interference with suppressor T-cell activation.
已知具有和不具有人IgG Fc受体的人外周血单核细胞亚群可在体外抑制（FcR+）和增强（FcR-）商陆丝裂原诱导的多克隆免疫球蛋白合成。研究了这些亚群在存在或不存在OKT8+ T细胞的情况下以及在通过照射或丝裂霉素C阻断抑制性T细胞活化的条件下调节免疫球蛋白产生的能力。结果表明，无论抑制性T细胞是否存在，如果培养物中FcR+单核细胞的数量超过20%，它们都可以抑制免疫球蛋白的产生。然而，当数量较低时，只有当抑制性T细胞被激活时，这个单核细胞亚群才具有抑制作用。抑制性T细胞的激活被证明与FcR+或FcR-单核细胞亚群的优势存在无关。此外，FcR-单核细胞的增强作用不是由它们对抑制性T细胞激活的干扰引起的。
