Dukur I I, Geller V I, Chizhov V A, Roĭkhel' V M, Pogodina V V
Vopr Virusol. 1986 Mar-Apr;31(2):220-5.
Histological examination of the central nervous system of naturally infected and dying minks revealed the picture of "status spongiosus" in the brains and spinal cords, lysis and loss of neurons, hypertrophy and proliferation of astroglia typical of transmissible mink encephalopathy (TME). The disease in minks was induced experimentally by oral, suboccipital, intramuscular, intraperitoneal, and subcutaneous routes of inoculation inducing typical clinical signs and histological lesions. Suspensions prepared from the infectious material obtained from the Institute of Poliomyelitis and Viral Encephalitides, Acad. Med. Sci. USSR. were used for inoculations. The incubation period varied from 7 to 9 months with different routes of inoculation. The infection could be reproduced by keeping the infected and normal animals together. Transmission of the disease from sick mothers to their offsprings was also observed. Electron microscopic studies revealed ultrastructural changes characteristic of transmissible encephalopathies.
对自然感染并濒死水貂的中枢神经系统进行组织学检查发现，其大脑和脊髓呈现出“海绵状状态”的图景，神经元溶解和丧失，出现了传染性水貂脑病（TME）典型的星形胶质细胞肥大和增殖。通过口服、枕下、肌肉内、腹腔内和皮下接种途径，在实验中诱发了水貂的这种疾病，引发了典型的临床症状和组织学病变。接种所用的悬液取自苏联医学科学院脊髓灰质炎和病毒性脑炎研究所获得的感染性材料。不同接种途径的潜伏期为7至9个月。将感染动物与正常动物饲养在一起可导致再次感染。还观察到了疾病从患病母兽传播给其后代的情况。电子显微镜研究揭示了传染性脑病特有的超微结构变化。
