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Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy?

作者信息

Chappell Lucy C, Chambers Jenny, Thornton Jim G, Williamson Catherine

机构信息

Women's Health Academic Centre, King's College London, London, UK

ICP Support, Sutton Coldfield, UK.

出版信息

BMJ. 2018 Feb 1;360:k104. doi: 10.1136/bmj.k104.

DOI:10.1136/bmj.k104
PMID:29419378
Abstract
摘要

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Does ursodeoxycholic acid improve perinatal outcomes in women with intrahepatic cholestasis of pregnancy?熊去氧胆酸能否改善妊娠肝内胆汁淤积症女性的围产期结局？
BMJ. 2018 Feb 1;360:k104. doi: 10.1136/bmj.k104.
2
[Intrahepatic cholestasis of pregnancy treated with ursodeoxycholic acid. Results from a two-year survey at Rigshospitalet, Skejby Hospital and Odense University Hospital].[用熊去氧胆酸治疗妊娠肝内胆汁淤积症。在丹麦哥本哈根大学医院、斯凯比医院和欧登塞大学医院进行的为期两年的调查结果]
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Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial.熊去氧胆酸对比安慰剂，以及早孕期分娩对比期待治疗，用于妊娠肝内胆汁淤积症妇女：半因子随机临床试验。
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[Intrahepatic cholestasis in pregnancy treated with ursodeoxycholic acid].[熊去氧胆酸治疗妊娠期肝内胆汁淤积症]
Ugeskr Laeger. 1999 Sep 27;161(39):5433-4.
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Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy. A retrospective study of 19 cases.熊去氧胆酸治疗妊娠期肝内胆汁淤积症。19例回顾性研究。
Acta Obstet Gynecol Scand. 2000 Nov;79(11):941-6.
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Pregnancy outcome in cases of intrahepatic cholestasis of pregnancy.妊娠期肝内胆汁淤积症患者的妊娠结局
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Pregnancy course in patients with intrahepatic cholestasis of pregnancy treated with very low doses of ursodeoxycholic acid.极低剂量熊去氧胆酸治疗妊娠期肝内胆汁淤积症患者的妊娠过程
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Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of pregnancy.熊去氧胆酸治疗妊娠期肝内胆汁淤积症。
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Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES).熊去氧胆酸与安慰剂治疗妊娠肝内胆汁淤积症（ICP）以改善围产期结局：一项随机对照试验（PITCHES）的方案
Trials. 2018 Nov 27;19(1):657. doi: 10.1186/s13063-018-3018-4.

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Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta.熊去氧胆酸抑制人胎盘中牛磺胆酸盐的摄取和血管收缩作用。
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