Bignon J, Sebastien P, Di Menza L, Payan H
Ann N Y Acad Sci. 1979;330:455-66. doi: 10.1111/j.1749-6632.1979.tb18747.x.
A total of 197 definite cases of mesothelioma (mainly of the pleura) have been reported by pathologists to the French Mesothelioma Register for the period 1965--78. A moderate linear increase in the annual incidence of mesothelioma cases since 1965 was noted. In men and women over the ages of 47 and 41 years, respectively, the annual death rate was higher in those with mesothelioma than in those of the general population. The proportions of mesothelioma patients who had experienced occupational, para-occupational, and unknown asbestos exposures were 77%, 3%, and 20% respectively. The number of cases reported to the register is obviously an underestimate of the true number of mesothelima cases in France, because such cases are not reported to the register systematically. Mesothelioma registers cannot provide information about dose-response relationships; however, with good management of the register, such relationships could be obtained, since a good assessment of dose can be accomplished by biologic monitoring.
1965年至1978年期间，病理学家向法国间皮瘤登记处报告了总共197例确诊的间皮瘤病例（主要是胸膜间皮瘤）。自1965年以来，间皮瘤病例的年发病率呈适度线性增长。在分别为47岁及以上的男性和41岁及以上的女性中，间皮瘤患者的年死亡率高于普通人群。经历过职业性、准职业性和不明石棉暴露的间皮瘤患者比例分别为77%、3%和20%。向登记处报告的病例数显然低估了法国间皮瘤病例的实际数量，因为此类病例并未系统地报告给登记处。间皮瘤登记处无法提供剂量反应关系的信息；然而，如果对登记处进行良好管理，就可以获得此类关系，因为通过生物监测可以很好地评估剂量。
