Bignon J, Sébastien P, Di Menza L, Nebut M, Payan H
Rev Fr Mal Respir. 1979 May-Jun;7(3):223-41.
A mesothelioma register was initiated in France in 1975 to record pathologists, cases diagnosed since 1965. These cases have been accepted as definite mesothelioma after histological reexamination by the mesothelioma panel. Histories of asbestos exposure have been recorded using a standardized questionnaire. Among 699 cases reported, 296 were confirmed and 79 excluded by the panel. Twenty per cent of cases were females. Tumour was located in the pleura in 96% of cases. Age at death was lower for the mesothelioma group than for the general population. A linear increase of annual incidence since 1965 has been observed. Mapping of cases showed irregular distribution with areas without any case. Distribution of cases according to asbestos exposure was the following: definite occupational history 50%, definite non-occupational 3%, possible occupational 31%, undiscovered 16%. Distribution of cases according to the latency period showed a two peaks-curve, median being 36 years. The obvious under-reporting of cases and the absence of control group greatly affected the validity of some results.
1975年法国启动了一个间皮瘤登记处，用以记录自1965年以来经病理学家诊断的病例。这些病例经间皮瘤专家小组进行组织学复查后被确认为确诊的间皮瘤。已使用标准化问卷记录石棉接触史。在报告的699例病例中，296例被专家小组确认为确诊病例，79例被排除。20%的病例为女性。96%的病例肿瘤位于胸膜。间皮瘤组的死亡年龄低于一般人群。自1965年以来观察到年发病率呈线性上升。病例分布图显示分布不规则，存在无病例的区域。根据石棉接触情况分类的病例分布如下：明确职业史50%，明确非职业性3%，可能职业性31%，未查明16%。根据潜伏期分类的病例分布呈双峰曲线，中位数为36年。病例明显报告不足以及缺乏对照组极大地影响了一些结果的有效性。
