Larsson-Cohn U, Fåhraeus L, von Schenck H, Wallentin L
Acta Obstet Gynecol Scand. 1986;65(2):125-8. doi: 10.3109/00016348609158366.
The effects on the lipoprotein metabolism of six cycles of treatment with 2 mg of the anti-androgenic progestogen Cyproterone acetate + 50 micrograms of ethinyl estradiol were prospectively studied in 22 healthy premenopausal women. The plasma level of cholesterol (C) was unchanged, while the levels of HDL-C and its subfractions HDL2-C and HDL3-C were significantly elevated after only one cycle. The LDL-C decreased after one month but then returned to pretreatment levels. VLDL-C was unchanged. The phospholipid concentrations within the various lipoprotein fractions generally resembled those of the corresponding cholesterol fraction. The levels of fibrinogen in plasma and of triglycerides in plasma and in the lipoprotein fractions were elevated. It is concluded that the drug had a predominant and rather pronounced estrogenic profile.
对22名健康的绝经前女性进行前瞻性研究，观察2毫克抗雄激素孕激素醋酸环丙孕酮+50微克炔雌醇六个周期治疗对脂蛋白代谢的影响。血浆胆固醇（C）水平未变，而高密度脂蛋白胆固醇（HDL-C）及其亚组分HDL2-C和HDL3-C水平仅在一个周期后就显著升高。低密度脂蛋白胆固醇（LDL-C）在一个月后下降，但随后又恢复到治疗前水平。极低密度脂蛋白胆固醇（VLDL-C）未变。各脂蛋白组分中的磷脂浓度总体上与相应胆固醇组分相似。血浆纤维蛋白原水平以及血浆和脂蛋白组分中的甘油三酯水平升高。结论是该药物具有主要且相当明显的雌激素特征。
