功能化二氟环丙烷的合成：药物发现的独特构建模块。
Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery.
机构信息
Enamine Ltd., Chervonotkatska 78, Kyiv, 02094, Ukraine.
Department of Chemistry, Taras Shevchenko National University of Kyiv, Volodymyrska 64, Kyiv, 01601, Ukraine.
出版信息
Chemistry. 2018 Aug 22;24(47):12291-12297. doi: 10.1002/chem.201705708. Epub 2018 Mar 25.
PMID:29419903
Abstract
Difluorocyclopropane-containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF /NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.
摘要
含二氟环丙烷的药物研发砌块可由功能化烯烃与 TMSCF/NaI 合成得到。新型氟化酸、胺、氨基酸、醇、酮和磺酰氯也可被合成得到。
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