Orchard S, Fellman J H, Storrs F J
Arch Dermatol. 1986 Jul;122(7):783-9. doi: 10.1001/archderm.122.7.783.
Closed patch tests were used to evaluate the ability of 156 different preparations (based on 22 different chemicals) to prevent poison ivy dermatitis. Several polyamine salts of a linoleic acid dimer were identified that were totally able to prevent the usual dermatitis in approximately 70% of subjects. The effectiveness of the preparations improved when the antigen and the protectant were washed off within eight to 12 hours, instead of remaining on the skin for 48 hours. When washed off, and depending on the protectant, concentration, and vehicle used, several of the preparations were totally able to prevent a dermatitis in a range of 56% to 100% of subjects tested. Further work with these compounds may greatly benefit the many people currently plagued by their allergy to poison ivy and poison oak.
采用封闭性斑贴试验来评估156种不同制剂（基于22种不同化学物质）预防毒漆藤皮炎的能力。已鉴定出几种亚油酸二聚体的多胺盐，它们能使大约70%的受试者完全预防常见的皮炎。当抗原和保护剂在8至12小时内被洗掉，而不是在皮肤上保留48小时时，制剂的有效性得到提高。洗掉后，根据所使用的保护剂、浓度和赋形剂，几种制剂能够使56%至100%的受试对象完全预防皮炎。对这些化合物开展进一步研究可能会使目前饱受毒漆藤和毒栎过敏困扰的众多人群受益匪浅。
