亨廷顿舞蹈症预测性检测的伦理问题：需要更多信息。
Ethics of predictive testing for Huntington's chorea: the need for more information.
作者信息
Craufurd D I, Harris R
出版信息
Br Med J (Clin Res Ed). 1986 Jul 26;293(6541):249-51. doi: 10.1136/bmj.293.6541.249.
Abstract
The finding of a genetically linked polymorphic DNA marker has made possible a predictive test for Huntington's chorea. This DNA probe has so far been used only for research and has technical limitations, but some workers now wish to apply it to clinical predictions. Those identified by the probe as being probable carriers of the Huntington's chorea gene would be exposed to uncertain psychological risks and social pressures. Ethical guidelines should be established, but these require greater knowledge of the potential benefits and hazards of this powerful new procedure. Controlled clinical trials are urgently needed.
摘要
发现一种与基因相关的多态性DNA标记使得对亨廷顿舞蹈病进行预测性检测成为可能。这种DNA探针目前仅用于研究，且存在技术限制，但一些研究人员现在希望将其应用于临床预测。那些被探针鉴定为可能携带亨廷顿舞蹈病基因的人将面临不确定的心理风险和社会压力。应该制定伦理准则，但这需要更深入了解这一强大的新程序的潜在益处和危害。迫切需要进行对照临床试验。
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