Centre for Adults with Grown-Up Congenital Heart Disease (GUCH), Sahlgrenska University Hospital/Östra, Sweden; Institute of Medicine, Dept. of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, Gothenburg University, Sweden.
Centre for Adults with Grown-Up Congenital Heart Disease (GUCH), Sahlgrenska University Hospital/Östra, Sweden; Institute of Medicine, Dept. of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, Gothenburg University, Sweden.
Int J Cardiol. 2018 Apr 15;257:46-49. doi: 10.1016/j.ijcard.2018.01.120. Epub 2018 Jan 31.
Despite the widespread use of percutaneous closure of patent foramen ovale (PFO) in patients after a cryptogenic stroke, little is known about its impact on health-related quality of life (HRQoL). The aim of this study was to assess HRQoL in these patients compared to PFO patients not considered candidates for percutaneous closure, and to a normal population.
A total of 402 patients with cryptogenic stroke or transient ischaemic attack (TIA) who had been referred to our center for PFO closure were invited to a long-term clinical follow-up (mean follow-up 5.5 years; range 3-13 years). HRQoL was assessed using the SF-36 Health Survey and data were compared with an age- and gender-matched reference group from the Swedish SF-36 normative database. Fifteen patients had died and 43 did not answer the SF-36. Of the remaining 344 patients, 208 had undergone PFO closure, and 136 had not. The closure group and reference group reported similar HRQoL levels. However, the non-closure group showed significantly lower HRQoL in role limitation - physical, vitality, general health, mental health (p < 0.05) and social functioning (p = 0.05) than the reference group and also had significantly lower scores than the closure group, correcting for age differences, on physical functioning, role limitation - physical, vitality and general health (p < 0.05).
Non-closure patients had lower HRQoL than their counterparts in the normal population and the closure group. Percutaneous PFO closure is associated with a favorable quality of life.
尽管卵圆孔未闭（PFO）经皮封堵术在隐源性卒中患者中广泛应用，但关于其对健康相关生活质量（HRQoL）影响的了解甚少。本研究旨在评估与未考虑经皮封堵术的 PFO 患者以及正常人群相比，这些患者的 HRQoL。
共邀请 402 名患有隐源性卒中或短暂性脑缺血发作（TIA）的患者参加我们中心的 PFO 封堵长期临床随访（平均随访时间为 5.5 年；范围 3-13 年）。使用 SF-36 健康调查评估 HRQoL，并将数据与来自瑞典 SF-36 正常数据库的年龄和性别匹配的参考组进行比较。15 名患者死亡，43 名患者未回答 SF-36。在其余 344 名患者中，208 名接受了 PFO 封堵，136 名未接受。封堵组和参考组报告的 HRQoL 水平相似。然而，未封堵组在身体角色受限、活力、总体健康、心理健康（p<0.05）和社会功能（p=0.05）方面的 HRQoL 明显低于参考组，且在身体功能、身体角色受限、活力和总体健康方面的评分也明显低于封堵组，在年龄差异校正后，差异具有统计学意义（p<0.05）。
未封堵患者的 HRQoL 低于正常人群和封堵组的患者。经皮 PFO 封堵与良好的生活质量相关。
