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Drugs that reduce transmission of falciparum malaria.减少恶性疟传播的药物。
Lancet Infect Dis. 2018 Jun;18(6):585-586. doi: 10.1016/S1473-3099(18)30070-7. Epub 2018 Feb 6.
2
Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial.在马里，采用磷酸萘酚喹和亚甲蓝预防疟原虫传播的效果和安全性：一项 2 期、单盲、随机对照试验。
Lancet Infect Dis. 2018 Jun;18(6):627-639. doi: 10.1016/S1473-3099(18)30044-6. Epub 2018 Feb 6.
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Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio.伯氨喹和亚甲蓝的传播阻断作用表明，恶性疟原虫配子体被绝育，而非对性别比例产生影响。
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Artemether-lumefantrine-amodiaquine or artesunate-amodiaquine combined with single low-dose primaquine to reduce Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a five-arm, phase 2, single-blind, randomised controlled trial.蒿甲醚-本芴醇-阿莫地喹或青蒿琥酯-阿莫地喹联合单剂量低剂量伯氨喹以减少马里韦莱塞布古恶性疟原虫疟疾传播：一项五臂、2期、单盲随机对照试验
Lancet Microbe. 2025 Feb;6(2):100966. doi: 10.1016/j.lanmic.2024.100966. Epub 2024 Dec 17.
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Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial.在马里使用伯氨喹减少恶性疟原虫疟疾传播：一项单盲、剂量范围、适应性随机2期试验。
Lancet Infect Dis. 2016 Jun;16(6):674-684. doi: 10.1016/S1473-3099(15)00479-X. Epub 2016 Feb 20.
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Pyronaridine-artesunate or dihydroartemisinin-piperaquine combined with single low-dose primaquine to prevent malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial.甲氟喹-青蒿琥酯或双氢青蒿素-哌喹联合单低剂量伯氨喹预防马里乌埃勒塞布布戈疟疾传播：一项四臂、单盲、2/3 期、随机试验。
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Gametocytocidal drugs: taking the population perspective.配子体杀灭药物：从群体角度考虑
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Artemether-lumefantrine with or without single-dose primaquine and sulfadoxine-pyrimethamine plus amodiaquine with or without single-dose tafenoquine to reduce Plasmodium falciparum transmission: a phase 2, single-blind, randomised clinical trial in Ouelessebougou, Mali.蒿甲醚-本芴醇加或不加单剂量磷酸萘酚喹与或不加单剂量磷酸泰法齐明加磺胺多辛-乙胺嘧啶预防恶性疟原虫传播的效果：马里乌莱塞布古的 2 期、单盲、随机临床试验。
Lancet Microbe. 2024 Jul;5(7):633-644. doi: 10.1016/S2666-5247(24)00023-5. Epub 2024 May 2.
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Methylene blue induced morphological deformations in Plasmodium falciparum gametocytes: implications for transmission-blocking.亚甲蓝诱导恶性疟原虫配子体形态畸形：对阻断传播的影响。
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Safety and efficacy of artesunate-amodiaquine combined with either methylene blue or primaquine in children with falciparum malaria in Burkina Faso: A randomized controlled trial.青蒿琥酯-阿莫地喹联合亚甲蓝或伯氨喹治疗布基纳法索儿童恶性疟的安全性和有效性：一项随机对照试验。
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The effect of single low-dose primaquine treatment for uncomplicated Plasmodium falciparum malaria on haemoglobin levels in Ethiopia: a longitudinal cohort study.单剂低剂量磷酸萘酚喹治疗无并发症恶性疟原虫疟疾对埃塞俄比亚血红蛋白水平的影响：一项纵向队列研究。
Malar J. 2024 Jul 12;23(1):208. doi: 10.1186/s12936-024-05021-x.
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Molecular surveillance over 14 years confirms reduction of Plasmodium vivax and falciparum transmission after implementation of Artemisinin-based combination therapy in Papua, Indonesia.14 年的分子监测证实，在印度尼西亚巴布亚实施基于青蒿素的联合疗法后，间日疟原虫和恶性疟原虫的传播得到了减少。
PLoS Negl Trop Dis. 2020 May 7;14(5):e0008295. doi: 10.1371/journal.pntd.0008295. eCollection 2020 May.
3
Molecular detection of P. vivax and P. ovale foci of infection in asymptomatic and symptomatic children in Northern Namibia.纳米比亚北部无症状和有症状儿童中 vivax 和 ovale 疟原虫感染焦点的分子检测。
PLoS Negl Trop Dis. 2019 May 1;13(5):e0007290. doi: 10.1371/journal.pntd.0007290. eCollection 2019 May.

本文引用的文献

1
Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial.在马里，采用磷酸萘酚喹和亚甲蓝预防疟原虫传播的效果和安全性：一项 2 期、单盲、随机对照试验。
Lancet Infect Dis. 2018 Jun;18(6):627-639. doi: 10.1016/S1473-3099(18)30044-6. Epub 2018 Feb 6.
2
The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study.大湄公河次区域青蒿素耐药恶性疟原虫的传播：一项分子流行病学观察性研究。
Lancet Infect Dis. 2017 May;17(5):491-497. doi: 10.1016/S1473-3099(17)30048-8. Epub 2017 Feb 2.
3
Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects.单次低剂量伯氨喹（0.25毫克/千克）不会在葡萄糖-6-磷酸脱氢酶（G6PD）缺乏的受试者中引起具有临床意义的溶血。
PLoS One. 2016 Mar 24;11(3):e0151898. doi: 10.1371/journal.pone.0151898. eCollection 2016.
4
Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial.在马里使用伯氨喹减少恶性疟原虫疟疾传播：一项单盲、剂量范围、适应性随机2期试验。
Lancet Infect Dis. 2016 Jun;16(6):674-684. doi: 10.1016/S1473-3099(15)00479-X. Epub 2016 Feb 20.
5
Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax.萘喹和亚甲蓝对恶性疟原虫和间日疟原虫耐药临床分离株的强大体外活性。
Antimicrob Agents Chemother. 2015 Oct;59(10):6117-24. doi: 10.1128/AAC.00874-15. Epub 2015 Jul 20.
6
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker.缅甸青蒿素耐药恶性疟原虫的传播：K13分子标记物的横断面调查
Lancet Infect Dis. 2015 Apr;15(4):415-21. doi: 10.1016/S1473-3099(15)70032-0. Epub 2015 Feb 20.
7
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.恶性疟原虫疟疾中配子体杀灭药物治疗反应的评估
Malar J. 2014 Dec 9;13:483. doi: 10.1186/1475-2875-13-483.
8
Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso.青蒿琥酯-阿莫地喹-亚甲蓝三联疗法治疗儿童恶性疟的疗效与安全性：布基纳法索的一项随机对照试验
J Infect Dis. 2015 Mar 1;211(5):689-97. doi: 10.1093/infdis/jiu540. Epub 2014 Sep 28.
9
Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs.亚甲蓝治疗无并发症恶性疟原虫感染的葡萄糖-6-磷酸脱氢酶（G6PD）正常和缺乏的西非儿童的溶血风险：四项 RCT 的概要。
Pharmacoepidemiol Drug Saf. 2013 Apr;22(4):376-85. doi: 10.1002/pds.3370. Epub 2012 Nov 7.
10
Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.亚甲蓝联合青蒿琥酯或阿莫地喹治疗非复杂性恶性疟的安全性和有效性：来自布基纳法索的一项随机对照试验
PLoS One. 2008 Feb 20;3(2):e1630. doi: 10.1371/journal.pone.0001630.

Drugs that reduce transmission of falciparum malaria.

作者信息

Price Ric N, White Nicholas J

机构信息

Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK; Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Lancet Infect Dis. 2018 Jun;18(6):585-586. doi: 10.1016/S1473-3099(18)30070-7. Epub 2018 Feb 6.

DOI:10.1016/S1473-3099(18)30070-7
PMID:29422385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5985155/
Abstract
摘要