White Nicholas J, Ashley Elizabeth A, Recht Judith, Delves Michael J, Ruecker Andrea, Smithuis Frank M, Eziefula Alice C, Bousema Teun, Drakeley Chris, Chotivanich Kesinee, Imwong Mallika, Pukrittayakamee Sasithon, Prachumsri Jetsumon, Chu Cindy, Andolina Chiara, Bancone Germana, Hien Tran T, Mayxay Mayfong, Taylor Walter R J, von Seidlein Lorenz, Price Ric N, Barnes Karen I, Djimdé Abdoulaye, ter Kuile Feiko, Gosling Roly, Chen Ingrid, Dhorda Mehul J, Stepniewska Kasia, Guérin Philippe, Woodrow Charles J, Dondorp Arjen M, Day Nicholas P J, Nosten Francois H
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Malar J. 2014 Dec 9;13:483. doi: 10.1186/1475-2875-13-483.
Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.
评估恶性疟原虫中抗疟药物传播阻断活性的间接临床指标包括测量配子体血症持续时间、配子体清除率或配子体血症-时间曲线下面积（AUC）。这些指标可能提供有用的比较信息，但它们低估了传播阻断活性的剂量-反应关系。给予8-氨基喹啉后，恶性疟原虫配子体在数小时内被灭活，而从血液中清除则需要数天。配子体血症AUC和清除时间主要由数量较多的雌配子体决定，雌配子体通常比少数雄配子体对药物更不敏感，而传播阻断活性以及由此产生的传染性则由更敏感的雄配子体形式决定。在选择传播阻断药物剂量时，目前尚无替代蚊虫叮咬研究的方法。
