Piper M C, Gosselin C, Gendron M, Mazer B
Child Care Health Dev. 1986 May-Jun;12(3):183-94. doi: 10.1111/j.1365-2214.1986.tb00497.x.
Thirty-two infants with Down's syndrome, who were enrolled in an early intervention programme were followed during the first 2 years of life. Progress in five developmental domains was monitored prospectively by evaluating the children at 6, 12, 18 and 24 months. The largest degree of retardation was consistently exhibited in the hearing and speech subscale. The locomotor subscale experienced the most severe decline over the 24 months and was the second most retarded domain at 2 years of age. The remaining three subscales, personal-social, hand-eye and performance, demonstrated less severe declines over time as well as actual increases in developmental quotients at specified points in time. The overall performance of female infants at 18 months was significantly better than that of male infants (P = 0.05). The degree of retardation of Down's syndrome infants receiving early intervention services differs according to chronological age, developmental domain and sex.
32名患有唐氏综合征的婴儿参加了一项早期干预项目，并在生命的头两年接受跟踪。通过在6、12、18和24个月时对儿童进行评估，前瞻性地监测五个发育领域的进展。听力和言语分量表始终表现出最大程度的发育迟缓。运动分量表在24个月内经历了最严重的下降，并且在2岁时是第二发育最迟缓的领域。其余三个分量表，即个人社交、手眼协调和操作，随着时间的推移表现出不太严重的下降，并且在特定时间点发育商数实际上有所增加。18个月大的女婴的总体表现明显优于男婴（P = 0.05）。接受早期干预服务的唐氏综合征婴儿的发育迟缓程度根据实际年龄、发育领域和性别而有所不同。
