Markland Alison, Hansen Gregory, Banks Anke, Chibbar Rajni, Adamko Darryl
University of Saskatchewan, Saskatoon, SK, Canada.
Division of Pediatric Intensive Care, University of Saskatchewan, Saskatoon, SK, Canada.
Case Rep Crit Care. 2017;2017:1050284. doi: 10.1155/2017/1050284. Epub 2017 Dec 20.
This report summarizes a case of a 4-year-old girl with poststreptococcal glomerulonephritis and diffuse alveolar hemorrhage, an atypical presentation in this age group and type of vasculitic disease. We propose that her rapid improvement in clinical status was due to her treatment, continuous renal replacement therapy (CRRT). This mechanism would have impacted recovery by removing factors such as endothelial microparticles, superantigens, and immune complexes that have been postulated as the pulmonary-renal link. This may be an interesting avenue of exploration going forward given the lack of evidence in treating such conditions and emergence of CRRT.
本报告总结了一例4岁女童的病例，该女童患有链球菌感染后肾小球肾炎和弥漫性肺泡出血，这在该年龄组和这种血管炎性疾病类型中属于非典型表现。我们认为她临床状况的迅速改善得益于她所接受的治疗，即持续肾脏替代疗法（CRRT）。这种机制可能通过清除诸如内皮微粒、超抗原和免疫复合物等被认为是肺肾关联因素而影响了康复。鉴于治疗此类病症缺乏证据以及CRRT的出现，这可能是未来一个有趣的探索方向。
