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Anti-Sez6l2 antibody detected in a patient with immune-mediated cerebellar ataxia inhibits complex formation of GluR1 and Sez6l2.

作者信息

Yaguchi Hiroaki, Yabe Ichiro, Takahashi Hidehisa, Watanabe Masashi, Nomura Taichi, Kano Takahiro, Watanabe Masahiko, Hatakeyama Shigetsugu

机构信息

Department of Neurology, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo, 060-8638, Japan.

Department of Biochemistry, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

出版信息

J Neurol. 2018 Apr;265(4):962-965. doi: 10.1007/s00415-018-8785-z. Epub 2018 Feb 8.

DOI:10.1007/s00415-018-8785-z
PMID:29423613
Abstract
摘要

相似文献

1
Anti-Sez6l2 antibody detected in a patient with immune-mediated cerebellar ataxia inhibits complex formation of GluR1 and Sez6l2.在一名免疫介导的小脑共济失调患者中检测到的抗Sez6l2抗体抑制了GluR1和Sez6l2的复合物形成。
J Neurol. 2018 Apr;265(4):962-965. doi: 10.1007/s00415-018-8785-z. Epub 2018 Feb 8.
2
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.Sez6l2调节ADD的磷酸化和神经突生成。
Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):234-241. doi: 10.1016/j.bbrc.2017.10.047. Epub 2017 Oct 12.
3
Long-term clinical follow-up of a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies.抗 mGluR1 自身抗体相关非副肿瘤性小脑共济失调患者的长期临床随访。
J Neuroimmunol. 2018 Jun 15;319:63-67. doi: 10.1016/j.jneuroim.2018.04.001. Epub 2018 Apr 4.
4
Fundamental Mechanisms of Autoantibody-Induced Impairments on Ion Channels and Synapses in Immune-Mediated Cerebellar Ataxias.免疫介导小脑共济失调中抗体诱导的离子通道和突触损伤的基本机制。
Int J Mol Sci. 2020 Jul 13;21(14):4936. doi: 10.3390/ijms21144936.
5
SEZ6L2 Antibody-Associated Cerebellar Ataxia Responsive to Sequential Immunotherapy.SEZ6L2 抗体相关小脑共济失调对序贯免疫治疗有反应。
Neurol Neuroimmunol Neuroinflamm. 2022 Jan 14;9(2). doi: 10.1212/NXI.0000000000001131. Print 2022 Mar.
6
Cerebellar ataxia as a possible organ-specific autoimmune disease.小脑性共济失调作为一种可能的器官特异性自身免疫性疾病。
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Sez6l2-antibody-associated progressive cerebellar ataxia: a differential diagnosis of atypical parkinsonism.与Sez6l2抗体相关的进行性小脑共济失调：非典型帕金森病的鉴别诊断
J Neurol. 2019 Feb;266(2):522-524. doi: 10.1007/s00415-018-9115-1. Epub 2018 Nov 20.
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Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects.与癫痫相关的 6 同源物样 2 自身免疫：神经综合征和抗体作用。
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9
Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy.在一名患有小脑共济失调和视网膜病变的患者中鉴定出抗Sez6l2抗体。
J Neurol. 2014 Jan;261(1):224-6. doi: 10.1007/s00415-013-7134-5. Epub 2013 Nov 23.
10
Cerebellar ataxia after malaria.疟疾后小脑性共济失调
Neurology. 2009 Jul 7;73(1):73-4. doi: 10.1212/WNL.0b013e3181aae9e6.

引用本文的文献

1
Sez6L2 autoimmunity induces cerebellar ataxia in mice.Sez6L2自身免疫在小鼠中诱发小脑共济失调。
bioRxiv. 2025 May 29:2025.05.28.656724. doi: 10.1101/2025.05.28.656724.
2
Autoimmune cerebellar ataxia associated with anti-SEZ6L2 antibody: report of three cases.与抗SEZ6L2抗体相关的自身免疫性小脑共济失调：三例报告
J Neurol. 2025 Jan 15;272(2):127. doi: 10.1007/s00415-024-12756-9.
3
A retrospective study of autoimmune cerebellar ataxia over a 20-year period in a single institution.在一家医疗机构 20 年期间对自身免疫性小脑性共济失调的回顾性研究。

本文引用的文献

1
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.Sez6l2调节ADD的磷酸化和神经突生成。
Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):234-241. doi: 10.1016/j.bbrc.2017.10.047. Epub 2017 Oct 12.
2
Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients.脑炎与AMPA受体抗体：22例病例系列研究中的新发现
Neurology. 2015 Jun 16;84(24):2403-12. doi: 10.1212/WNL.0000000000001682. Epub 2015 May 15.
3
Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.共识文件：小脑共济失调的神经免疫机制
J Neurol. 2024 Jan;271(1):553-563. doi: 10.1007/s00415-023-11946-1. Epub 2023 Aug 23.
4
Utility of Protein Microarrays for Detection of Classified and Novel Antibodies in Autoimmune Neurologic Disease.蛋白质微阵列在自身免疫性神经疾病分类和新型抗体检测中的应用。
Neurol Neuroimmunol Neuroinflamm. 2023 Aug 7;10(5). doi: 10.1212/NXI.0000000000200145. Print 2023 Sep.
5
Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry.通过质谱分析发现膜性肾病和狼疮性肾炎中七个新的潜在抗原。
Kidney Int. 2023 Mar;103(3):593-606. doi: 10.1016/j.kint.2023.01.001. Epub 2023 Jan 10.
6
Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature.副肿瘤性小脑综合征中的抗SEZ6L2抗体：病例报告及文献综述
Neurol Res Pract. 2022 Oct 31;4(1):54. doi: 10.1186/s42466-022-00218-4.
7
Novelties in Autoimmune and Paraneoplastic Cerebellar Ataxias: Twenty Years of Progresses.自身免疫性和副肿瘤性小脑共济失调的新进展：二十年的进展。
Cerebellum. 2022 Aug;21(4):573-591. doi: 10.1007/s12311-021-01363-3. Epub 2022 Jan 12.
8
Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia.自身免疫性运动障碍的最新进展：自身免疫性和副肿瘤性小脑共济失调中新描述的抗原靶点
Front Neurol. 2021 Aug 18;12:683048. doi: 10.3389/fneur.2021.683048. eCollection 2021.
9
Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects.与癫痫相关的 6 同源物样 2 自身免疫：神经综合征和抗体作用。
Neurol Neuroimmunol Neuroinflamm. 2020 Nov 3;8(1). doi: 10.1212/NXI.0000000000000916. Print 2021 Jan.
10
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Cell-surface central nervous system autoantibodies: clinical relevance and emerging paradigms.细胞表面中枢神经系统自身抗体：临床相关性及新出现的模式
Ann Neurol. 2014 Aug;76(2):168-84. doi: 10.1002/ana.24200. Epub 2014 Jul 10.
5
Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy.在一名患有小脑共济失调和视网膜病变的患者中鉴定出抗Sez6l2抗体。
J Neurol. 2014 Jan;261(1):224-6. doi: 10.1007/s00415-013-7134-5. Epub 2013 Nov 23.
6
TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis.TRIM67 蛋白通过降解 80K-H 负调控 Ras 活性并诱导神经突生成。
J Biol Chem. 2012 Apr 6;287(15):12050-9. doi: 10.1074/jbc.M111.307678. Epub 2012 Feb 15.
7
Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer.SEZ6L2细胞表面蛋白作为肺癌新型预后标志物的特征分析
Cancer Sci. 2006 Aug;97(8):737-45. doi: 10.1111/j.1349-7006.2006.00258.x.
8
Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family.缺乏新型脑特异性受体样蛋白家族BSRPs的突变小鼠中，小脑突触成熟受到干扰。
FEBS Lett. 2006 Jul 24;580(17):4057-64. doi: 10.1016/j.febslet.2006.06.043. Epub 2006 Jun 27.