Instituto de Investigacion Cientifica, Universidad Juarez del Estado de Durango, Durango, Mexico.
Facultad de Medicina y Nutricion, Universidad Juarez del Estado de Durango, Durango, Mexico.
CNS Neurol Disord Drug Targets. 2018 Apr 26;17(1):69-74. doi: 10.2174/1871527317666180207165238.
Depressive disorders are common during pregnancy. There is compelling evidence that the inflammatory response system is important in the pathophysiology of depression. Higher concentrations of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-α) in depressed subjects have been described. Because several polymorphisms in the TNF-α promoter region are known to affect its gene expression, the aim of this study was determine whether TNF-α - 857C/T, -308G/A, and -238G/A polymorphisms confer susceptibility to depression during pregnancy in a Mexican mestizo population.
This case-control study involved 153 depressed pregnant women and 177 controls. Polymorphisms were genotyped using real-time PCR. Odds ratios (OR) and 95% confidence intervals adjusted by age, body mass index, number of pregnancies, months of pregnancy and number of abortions were used to estimate risk.
The -857CT genotype was found to increase the risk for depression (OR= 1.73, 95% CI= 1.06-2.82). In contrast, the -238GA genotype reduced the risk (OR= 0.33, 95% CI= 0.14-0.72). The - 308G/A polymorphism was not associated with risk for depression. Finally, the C857-G308-A238 haplotype was associated with a decreased risk of depression (OR= 0.35, 95% CI= 0.15-0.82).
Our results show for the first time an association between TNF-α -857C/T and -238G/A polymorphisms and prenatal depression in Mexican mestizo population.
抑郁障碍在怀孕期间很常见。有强有力的证据表明，炎症反应系统在抑郁症的病理生理学中很重要。已经描述了抑郁患者中包括肿瘤坏死因子-α（TNF-α）在内的促炎细胞因子浓度升高。由于 TNF-α 启动子区域的几个多态性已知会影响其基因表达，因此本研究的目的是确定 TNF-α-857C/T、-308G/A 和-238G/A 多态性是否在墨西哥梅斯蒂索人群中导致怀孕期间易患抑郁症。
本病例对照研究纳入了 153 名抑郁孕妇和 177 名对照。使用实时 PCR 对多态性进行基因分型。使用调整年龄、体重指数、妊娠次数、妊娠月数和流产次数的优势比（OR）和 95%置信区间来估计风险。
-857CT 基因型被发现增加了患抑郁症的风险（OR=1.73，95%CI=1.06-2.82）。相反，-238GA 基因型降低了风险（OR=0.33，95%CI=0.14-0.72）。-308G/A 多态性与抑郁症风险无关。最后，C857-G308-A238 单倍型与抑郁症风险降低相关（OR=0.35，95%CI=0.15-0.82）。
我们的结果首次表明，TNF-α-857C/T 和-238G/A 多态性与墨西哥梅斯蒂索人群产前抑郁症有关。
