a Department of Primary and Community Care , Center for Family Medicine, Geriatric Care and Public Health , Radboud University Nijmegen , Medical Centre , Nijmegen , the Netherlands.
b Archipel, Landrijt , Knowledge Center For Specialized Care , Eindhoven , the Netherlands.
Aging Ment Health. 2019 May;23(5):581-586. doi: 10.1080/13607863.2018.1428935. Epub 2018 Feb 9.
The aims of the current study are (1) to explore the differences in neuropsychiatric symptoms (NPS) between young-onset dementia (YOD) and late-onset dementia (LOD), and (2) to investigate whether the possible differences can be attributed to differences in dementia subtype, gender, psychotropic drug use (PDU), or dementia severity.
Three hundred and eighty-six nursing home (NH) residents with YOD and 350 with LOD were included. Multilevel modeling was used to compare NPS between the groups . Furthermore, dementia subtype, gender, PDU, and dementia severity were added to the crude multilevel models to investigate whether the possible differences in NPS could be attributed to these characteristics.
Higher levels of apathy were found in NH residents with YOD. After the characteristics were added to the models, also lower levels of verbally agitated behaviors were found in YOD .
We recommend that special attention be paid to interventions targeting apathy in YOD. Although no differences in other NPS were found, the PDU rates were higher in YOD, suggesting that the threshold for the use of PDU in the management of NPS is lower. This underscores the need for appropriate attention to non-pharmacological interventions for the management of NPS in YOD.
本研究旨在（1）探讨早发性痴呆（YOD）与晚发性痴呆（LOD）患者神经精神症状（NPS）的差异，（2）探究这些差异是否归因于痴呆亚型、性别、精神药物使用（PDU）或痴呆严重程度的不同。
共纳入 386 例养老院 YOD 患者和 350 例 LOD 患者。采用多水平模型比较两组间 NPS 的差异。进一步将痴呆亚型、性别、PDU 和痴呆严重程度纳入到原始多水平模型中，以探究 NPS 的差异是否归因于这些特征。
YOD 患者的淡漠症状更为严重。在加入特征后，YOD 患者的言语激越行为也更少。
我们建议特别关注 YOD 患者的淡漠干预措施。尽管其他 NPS 无差异，但 YOD 的 PDU 使用率更高，这表明在管理 NPS 时，使用 PDU 的阈值更低。这强调了在 YOD 中，管理 NPS 需要适当关注非药物干预措施。
