肿瘤坏死因子超家族成员4（TNFSF4）基因多态性（rs3850641和rs17568）与冠心病和中风的关联性缺失：一项系统综述和荟萃分析

Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis.

作者信息

Lu Jin Sen, Wang Hong, Yuan Fei Fei, Wu Le Le, Wang Bin, Ye Dong Qing

机构信息

Anhui Province Key Laboratory of Major Autoimmune Diseases; Anhui- P. R. China.

出版信息

Anatol J Cardiol. 2018 Feb;19(2):86-93. doi: 10.14744/AnatolJCardiol.2017.8069.

DOI:10.14744/AnatolJCardiol.2017.8069

PMID:29424751

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5864823/

Abstract

OBJECTIVE

To evaluate the association between the tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms and common cardiovascular and cerebrovascular diseases.

METHODS

A literature-based search was conducted through databases including PubMed, EMBASE, Cochrane Library, CNKI, and WanFang data. Crude odds ratios (ORs) and 95% confidence intervals (CI) were calculated to estimate the strength of the association between TNFSF4 polymorphisms (rs3850641 and rs17568) and the risk of coronary heart disease (CHD) and stroke.

RESULTS

Overall, 11 eligible studies were included in this meta-analysis. G allele was showed not to be associated with CHD and stroke, compared with A allele (rs3850641: OR=1.02, 95% CI=0.89-1.17; rs17568: OR=1.09, 95% CI=0.89-1.33). Genotypic analysis demonstrated that there was no significant association between the risk of CHD and stroke and rs3850641 [homozygous comparison (GG vs. AA): OR=1.05, 95% CI=0.74-1.50; heterozygous comparison (GA vs. AA): OR=1.00, 95% CI=0.88-1.13; recessive model (GG vs. GA+AA): OR=1.04, 95% CI=0.76-1.43; dominant model (GG+GA vs. AA): OR=1.01, 95% CI=0.88-1.17]. Similarly, no susceptibility between CHD and stroke and rs17568 polymorphism was uncovered (GG vs. AA: OR=1.04, 95% CI=0.74-1.46; GA vs. AA: OR=1.07, 95% CI=0.62-1.83; GG+GA vs. AA: OR=1.13, 95% CI=0.82-1.56; GG vs. GA+AA: OR=1.01, 95% CI=0.74-1.39).

CONCLUSION

The present study demonstrated that there is no significant relationship between TNFSF4 gene polymorphism and cerebrovascular and cardiovascular diseases.

摘要

目的

评估肿瘤坏死因子超家族成员4（TNFSF4）基因多态性与常见心脑血管疾病之间的关联。

方法

通过PubMed、EMBASE、Cochrane图书馆、中国知网和万方数据等数据库进行基于文献的检索。计算粗比值比（OR）和95%置信区间（CI），以估计TNFSF4多态性（rs3850641和rs17568）与冠心病（CHD）和中风风险之间关联的强度。

结果

总体而言，本荟萃分析纳入了11项符合条件的研究。与A等位基因相比，G等位基因与冠心病和中风无关（rs3850641：OR = 1.02，95% CI = 0.89 - 1.17；rs17568：OR = 1.09，95% CI = 0.89 - 1.33）。基因型分析表明，冠心病和中风风险与rs3850641之间无显著关联[纯合子比较（GG vs. AA）：OR = 1.05，95% CI = 0.74 - 1.50；杂合子比较（GA vs. AA）：OR = 1.00，95% CI = 0.88 - 1.1；隐性模型（GG vs. GA + AA）：OR = 1.04，95% CI = 0.76 - 1.43；显性模型（GG + GA vs. AA）：OR = 1.01，95% CI = 0.88 - 1.17]。同样，未发现冠心病和中风与rs17568多态性之间存在易感性（GG vs. AA：OR = 1.04，95% CI = 0.74 - 1.46；GA vs. AA：OR = 1.07，95% CI = 0.62 - 1.83；GG + GA vs. AA：OR = 1.13，95% CI = 0.82 - 1.56；GG vs. GA + AA：OR = 1.01，95% CI = 0.74 - 1.39）。