中国人群中动脉粥样硬化性脑梗死与TNFSF4/TNFRSF4单核苷酸多态性rs1234313、rs1234314和rs17568之间无关联。
Absence of association between atherosclerotic cerebral infarction and TNFSF4/TNFRSF4 single nucleotide polymorphisms rs1234313, rs1234314 and rs17568 in a Chinese population.
作者信息
Huang Qing, Yang Qi-Dong, Tan Xing-Lin, Feng Jie, Tang Tao, Xia Jian, Zhang Le, Huang Li, Bai Yong-Ping, Liu Yun-Hai
机构信息
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
出版信息
J Int Med Res. 2014 Apr;42(2):436-43. doi: 10.1177/0300060514521154. Epub 2014 Mar 4.
OBJECTIVE
To clarify the association between atherosclerotic cerebral infarction (ACI) and the single nucleotide polymorphisms (SNP) rs1234313 and rs1234314 (in TNFSF4) and rs17568 (in TNFRSF4).
METHODS
Genomic DNA was extracted from peripheral blood of patients with ACI and healthy control subjects. The presence of carotid plaque was determined. Rs1234313, rs1234314 and rs17568 were characterized via SNP genotyping assay and verified by DNA sequencing.
RESULTS
Genotype distributions were in Hardy-Weinberg equilibrium. There were no significant differences in the allele and genotype distributions of rs1234313, rs1234314 and rs17568 between patients with ACI (n = 450) and healthy control subjects (n = 378), or between patients with ACI and carotid plaque (n = 342) and controls.
CONCLUSIONS
There were no significant associations between rs1234313, rs1234314 and rs17568 and ACI risk in a Han Chinese population.
目的
阐明动脉粥样硬化性脑梗死（ACI）与单核苷酸多态性（SNP）rs1234313和rs1234314（位于TNFSF4基因）以及rs17568（位于TNFRSF4基因）之间的关联。
方法
从ACI患者和健康对照者的外周血中提取基因组DNA。确定颈动脉斑块的存在情况。通过SNP基因分型检测对rs1234313、rs1234314和rs17568进行分型，并通过DNA测序进行验证。
结果
基因型分布符合哈迪-温伯格平衡。在ACI患者（n = 450）与健康对照者（n = 378）之间，以及ACI合并颈动脉斑块患者（n = 342）与对照者之间，rs1234313、rs1234314和rs17568的等位基因和基因型分布均无显著差异。
结论
在汉族人群中，rs1234313、rs1234314和rs17568与ACI风险之间无显著关联。
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