miR-597 低表达与乳腺癌的肿瘤分期和不良预后相关。

Low expression of miR-597 is correlated with tumor stage and poor outcome in breast cancer.

机构信息

Department of Oncology, Daqing Oilfield General Hospital, Daqing, Heilongjiang, China.

出版信息

Eur Rev Med Pharmacol Sci. 2018 Jan;22(2):456-460. doi: 10.26355/eurrev_201801_14195.

DOI:10.26355/eurrev_201801_14195

PMID:29424903

Abstract

OBJECTIVE

MicroRNAs (miRNAs) have been reported to play important roles in the progression of breast cancer (BC). In the present study, we aimed to explore the association between miR-597 expression level and prognosis of BC.

PATIENTS AND METHODS

The expression levels of miR-597 were measured using quantitative Real-time polymerase chain reaction (qRT-PCR) analysis. The association between miR-597 expression and clinicopathological factors was analyzed. Differences in BC patient survival were determined using the Kaplan-Meier method and log-rank test. The prognostic value of miR-597 was further verified using the Cox proportional hazards regression model.

RESULTS

Our data indicated that miR-597 was lowly expressed in BC compared with adjacent non-malignant tissues (p<0.001). Low miR-597 expression was observed to be closely associated with positive lymph node metastasis (p=0.001), higher TNM stage (p = 0.003), and poorer pathological differentiation (p=0.006). Furthermore, patients with lower levels of miR-597 expression had a shorter overall survival time than patients with higher miR-597 expression levels (p=0.009). In addition, multivariate Cox proportional hazards model analysis confirmed that miR-597 was an independent prognostic indicator of overall survival (p=0.005; HR 2.273; CI 95%, 1.117-4.291).

CONCLUSIONS

We showed, for the first time, that decreased miR-597 expression suggested unfavorable prognosis for BC patients.

摘要

目的

已有研究表明 microRNAs（miRNAs）在乳腺癌（BC）的进展中发挥着重要作用。本研究旨在探讨 miR-597 表达水平与 BC 患者预后的关系。

方法

采用实时定量聚合酶链反应（qRT-PCR）分析检测 miR-597 的表达水平。分析 miR-597 表达与临床病理因素的关系。采用 Kaplan-Meier 法和对数秩检验比较 BC 患者的生存差异。进一步采用 Cox 比例风险回归模型验证 miR-597 的预后价值。

结果

我们的数据表明，miR-597 在 BC 组织中的表达水平明显低于癌旁非恶性组织（p＜0.001）。miR-597 低表达与阳性淋巴结转移（p=0.001）、较高的 TNM 分期（p=0.003）和较差的病理分化（p=0.006）密切相关。此外，miR-597 低表达患者的总生存期短于 miR-597 高表达患者（p=0.009）。多因素 Cox 比例风险模型分析证实，miR-597 是总生存期的独立预后指标（p=0.005；HR 2.273；95%CI 1.117-4.291）。