Liolios Themis, Kastora Stavroula Lila, Colombo Giorgia
Hellenic Republic National and Kapodistrian, University of Athens, Faculty of Biology, Athens, Greece.
University of Aberdeen, School of Medicine and Dentistry, Aberdeen, UK.
Cancer Inform. 2019 Feb 13;18:1176935119828746. doi: 10.1177/1176935119828746. eCollection 2019.
MicroRNAs (miRNAs) are endogenous 22-nucleotide RNAs that can play a fundamental regulatory role in the gene expression of various organisms. Current research suggests that miRNAs can assume pivotal roles in carcinogenesis. In this article, through bioinformatics mining and computational analysis, we determine a single miRNA commonly involved in the development of breast, cervical, endometrial, ovarian, and vulvar cancer, whereas we underline the existence of 7 more miRNAs common in all examined malignancies with the exception of vulvar cancer. Furthermore, we identify their target genes and encoded biological functions. We also analyze common biological processes on which all of the identified miRNAs act and we suggest a potential mechanism of action. In addition, we analyze exclusive miRNAs among the examined malignancies and bioinformatically explore their functionality. Collectively, our data can be employed in in vitro assays as a stepping stone in the identification of a universal machinery that is derailed in female malignancies, whereas exclusive miRNAs may be employed as putative targets for future chemotherapeutic agents or cancer-specific biomarkers.
微小RNA（miRNA）是一种内源性22个核苷酸的RNA，可在各种生物体的基因表达中发挥重要的调节作用。目前的研究表明，miRNA在癌症发生过程中可能发挥关键作用。在本文中，通过生物信息学挖掘和计算分析，我们确定了一种在乳腺癌、宫颈癌、子宫内膜癌、卵巢癌和外阴癌发展过程中共同涉及的单一miRNA，同时我们强调除外阴癌外，在所有检测的恶性肿瘤中还存在另外7种常见的miRNA。此外，我们确定了它们的靶基因和编码的生物学功能。我们还分析了所有已鉴定的miRNA所作用的共同生物学过程，并提出了一种潜在的作用机制。此外，我们分析了所检测的恶性肿瘤中的特异性miRNA，并通过生物信息学方法探索了它们的功能。总的来说，我们的数据可用于体外试验，作为识别在女性恶性肿瘤中失调的通用机制的垫脚石，而特异性miRNA可作为未来化疗药物或癌症特异性生物标志物的假定靶点。
