Department of Hand and Reconstructive Microsurgery, National University Hospital, 1E Kent Ridge Road, NUHS Tower Block, Level 11, Singapore, 119228, Singapore.
School of Materials Science and Engineering, Nanyang Technological University, Block No. 4.1, 50 Nanyang Avenue, Singapore, 639798, Singapore.
J Biomed Mater Res B Appl Biomater. 2018 Oct;106(7):2605-2614. doi: 10.1002/jbm.b.34077. Epub 2018 Feb 9.
Progressive tendon adhesion is a major challenge in flexor tendon repair. The authors developed a bifunctional anti-adhesion scaffold and hypothesized that its application would reduce adhesion formation and deliver mesenchymal stem cells (MSCs) to enhance tendon healing. The scaffold was fabricated by an electrospinning machine before surface modification. The flexor tendons of 29 New Zealand rabbits underwent surgical repair and randomized to control, scaffold and scaffold loaded with MSC group. At 3 and 8 weeks post-surgery, range of motion (ROM), biomechanical properties, and histology were examined. There was no significant increase in ROM and biomechanical properties between the three groups. The histology showed successful delivery of MSCs but no significant difference in nuclear morphometry. This barrier delivers and retains MSCs within the tendon repair site. However, its sheet form and wrapping around the repair site may not be optimal for tendon healing. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2605-2614, 2018.
进行性肌腱粘连是屈肌腱修复的主要挑战。作者研制了一种双功能抗粘连支架，并假设其应用可减少粘连形成并输送间充质干细胞（MSCs）以增强肌腱愈合。支架在进行表面改性之前通过静电纺丝机制造。29 只新西兰兔的屈肌腱接受手术修复并随机分为对照组、支架组和支架加载 MSC 组。术后 3 周和 8 周，检查了运动范围（ROM）、生物力学特性和组织学。三组间 ROM 和生物力学性能均无显著增加。组织学显示 MSC 成功传递，但核形态计量学无显著差异。该屏障可将 MSC 递送至并保留在肌腱修复部位。然而，其片状形式和围绕修复部位包裹可能不利于肌腱愈合。© 2018 Wiley Periodicals, Inc. J 生物材料研究杂志 B：应用生物材料，106B：2605-2614，2018 年。
