Department of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, 310003, Zhejiang Province, People's Republic of China.
Tissue Eng Regen Med. 2021 Feb;18(1):1-14. doi: 10.1007/s13770-020-00300-5. Epub 2020 Nov 4.
Peritendinous adhesion that simultaneous with tendon healing link the healing tendon to the surrounding tissue. It results in functional disability, and has a significant adverse impact on health as well as social and economic development.
Based on a search in the PubMed and Web of Science database, the research articles were screened by their time, main idea, impact factor index, while the ones with no credibility were excluded. Afterwards, we go through the analysis of the reliability and characteristics of the results were further screened from selected articles.
A total of 17 biomaterials used to evaluate the adhesion mechanism and the properties of the material were found. All of these biomaterials contained randomized controlled studies and detailed descriptions of surgical treatment that support the reliability of their results which indicates that biomaterials act as barriers to prevent the formation of adhesion, and most of them exhibit satisfactory biocompatibility, biodegradability or selective permeability. Moreover, a few had certain mechanical strength, anti-inflammatory, or carrier capacities. However, there still existed some defects, such as time, technology, clinical trials, material targeting and different measurement standards which also lowered the reliability of their results.
In future, anti-adhesion biomaterials should focus on affordable raw materials with wide sources, and the production process should be simplified, in this way, the versatility and targeting of materials will be improved.
伴随腱愈合同时出现的腱周粘连将愈合的肌腱与周围组织连接起来。它导致功能障碍，并对健康以及社会和经济发展产生重大不利影响。
基于对 PubMed 和 Web of Science 数据库的搜索，通过时间、主要思想、影响因子指数对研究文章进行筛选，同时排除不可信的文章。然后，我们对所选文章的可靠性和结果特征进行分析，进一步筛选。
共发现 17 种生物材料用于评估粘连机制和材料性能。所有这些生物材料都包含随机对照研究和详细的手术治疗描述，支持其结果的可靠性，这表明生物材料作为屏障防止粘连形成，其中大多数表现出令人满意的生物相容性、可生物降解性或选择性渗透性。此外，有一些还具有一定的机械强度、抗炎或载体能力。然而，仍然存在一些缺陷，例如时间、技术、临床试验、材料靶向和不同的测量标准，这也降低了其结果的可靠性。
未来，抗粘连生物材料应着眼于负担得起的原材料，来源广泛，生产过程应简化，从而提高材料的通用性和靶向性。
