Ferreira Rosângela Dos Santos, Guimarães Rita de Cássia Avellaneda, Pontes Elenir Rose Jardim Cury, Mendonça Lígia Aurélio Bezerra Maranhão, Freitas Karine de Cássia, Hiane Priscila Aiko
Nutrition Service, University Hospital, Federal University of Mato Grosso do Sul-UFMS, Campo Grande, Mato Grosso do Sul, Brazil.
Post Graduate Program in Biotechnology, Catholic University Dom Bosco, Campo Grande, Mato Grosso do Sul, Brazil.
PLoS One. 2018 Feb 9;13(2):e0191259. doi: 10.1371/journal.pone.0191259. eCollection 2018.
Highly Active Antiretroviral therapy (HAART) promotes anthropometric changes in lipid metabolism and glucose in patients with Human Immunodeficiency Virus (HIV). Functional foods play an important role on metabolism. Bioactive Food Compound (BFC) has shown effective results in changes arising from decompensated lipid metabolism due to the effects of HAART on HIV patients. From this perspective, the objective of this study is to evaluate anthropometric indicators and the body composition of patients undergoing HAART before and after consumption of BFC.
This is a prospective intervention with 180 individuals with HIV undergoing HAART. They formed two groups and were monitored for 3 months: the first group consisted of individuals who consumed BFC (n = 121) at the recommended daily intake of 40 g. The second group consisted of individuals who did not consume BFC (n = 59). We determined body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), conicity index (CI) and antiretroviral regimen used by the patients.
The BMI among adults (p<0.001), the WC (p<0.001 and p<0.014 for men and women, respectively) and the CI (p = 0.001 and p<0.001 for men and women, respectively) increased at the end of the study in the group of individuals who did not consume BFC and remained stable in the BFC group. There were no changes in WHR in any of the groups evaluated. Regarding the antiretroviral regimens used, we observed that there was no difference between regimens as for BMI, WC, WHR and CI.
The BFC consumed by HIV patients undergoing HAART allowed the maintenance of anthropometric measures without increasing the mean values of conicity index, suggesting that the consumption of this bioactive compound protects the individual against the development of metabolic syndrome (MeS) in patients infected with HIV undergoing antiretroviral therapy.
高效抗逆转录病毒疗法（HAART）会促使感染人类免疫缺陷病毒（HIV）的患者在人体测量学、脂质代谢及血糖方面发生变化。功能性食品对新陈代谢起着重要作用。生物活性食品化合物（BFC）已显示出对因HAART作用于HIV患者而导致的脂质代谢失代偿所引发的变化具有有效作用。从这一角度来看，本研究的目的是评估接受HAART治疗的患者在食用BFC前后的人体测量指标和身体成分。
这是一项针对180名接受HAART治疗的HIV感染者的前瞻性干预研究。他们被分成两组，并接受3个月的监测：第一组由按照每日推荐摄入量40克食用BFC的个体组成（n = 121）。第二组由未食用BFC的个体组成（n = 59）。我们测定了患者的体重指数（BMI）、腰围（WC）、腰臀比（WHR）、锥度指数（CI）以及所使用的抗逆转录病毒治疗方案。
在未食用BFC的个体组中，研究结束时成年人的BMI（p<0.001）、WC（男性p<0.001，女性p<0.014）和CI（男性p = 0.001，女性p<0.001）均有所增加，而在BFC组中则保持稳定。在任何评估组中WHR均无变化。关于所使用的抗逆转录病毒治疗方案，我们观察到不同方案在BMI、WC、WHR和CI方面没有差异。
接受HAART治疗的HIV患者食用的BFC能够维持人体测量指标，而不增加锥度指数的平均值，这表明食用这种生物活性化合物可保护个体在接受抗逆转录病毒治疗的HIV感染者中预防代谢综合征（MeS）的发生。
