Dos Santos Ferreira Rosângela, de Cássia Avellaneda Guimarães Rita, Jardim Cury Pontes Elenir Rose, Aragão do Nascimento Valter, Aiko Hiane Priscila
Nutrition Service, University Hospital, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, MS, Brazil.
Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, MS, Brazil.
Nutrients. 2016 Oct 8;8(10):598. doi: 10.3390/nu8100598.
Cardiovascular events due to decompensated lipid metabolism are commonly found in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) patients using anti-retroviral therapy (HAART). Thus, the aim of this study was to identify the effect of a bioactive food compound (BFC) containing functional foods on individuals with HIV undergoing HAART. Particularly, this study aims to verify the clinical outcome in the change of the lipid profile due to the use of this compound. This study includes 115 individuals with HIV on HAART. All patients received dietary guidelines; however, sixty-one consumed BFC while fifty-one did not (NO BFC). Biochemical examinations and socio-demographic and clinical profiles were evaluated. As result, in patients using hypolipidemic and/or hypoglycemic drugs, there was 28.6% decrease in triglyceride levels ( < 0.001) in the NO BFC group, and 18.3% reduction in low density lipoprotein cholesterol (LDL-C) ( < 0.001) in the BFC group. In patients who did not use hypolipidemic and/or hypoglycemic drugs in the NO BFC group, there was 30.6% increase in triglycerides, 11.3% total cholesterol and 15.3% LDL-C levels ( < 0.001) while for the BFC group there was 4.5% reduction in total cholesterol ( < 0.001). In conclusion, this study evidenced that the dietary intervention containing BFC positively affected in lipid control, since these HIV/AIDS patients using HAART are more vulnerable to lipid disorders.
在接受抗逆转录病毒疗法（HAART）的人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）患者中，常出现因脂质代谢失代偿导致的心血管事件。因此，本研究的目的是确定含有生物活性食品化合物（BFC）的功能性食品对接受HAART的HIV感染者的影响。特别是，本研究旨在验证使用该化合物后血脂谱变化的临床结果。本研究纳入了115例接受HAART的HIV感染者。所有患者均接受了饮食指导；然而，61人食用了BFC，而51人未食用（未食用BFC）。对生化检查以及社会人口统计学和临床特征进行了评估。结果显示，在使用降血脂和/或降血糖药物的患者中，未食用BFC组的甘油三酯水平下降了28.6%（<0.001），而食用BFC组的低密度脂蛋白胆固醇（LDL-C）降低了18.3%（<0.001）。在未食用BFC组中未使用降血脂和/或降血糖药物的患者中，甘油三酯水平升高了30.6%，总胆固醇升高了11.3%，LDL-C水平升高了15.3%（<0.001），而食用BFC组的总胆固醇降低了4.5%（<0.001）。总之，本研究证明，含有BFC的饮食干预对血脂控制有积极影响，因为这些接受HAART的HIV/AIDS患者更容易出现脂质紊乱。
