兄弟守护者：野生型突变型 K-Ras 二聚体限制致癌作用。
Brother's Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis.
机构信息
Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
出版信息
Cell. 2018 Feb 8;172(4):645-647. doi: 10.1016/j.cell.2018.01.019.
K-Ras is the undisputed champion of oncogenes, yet our ability to interfere with its oncogenic function is hampered by insufficient mechanistic understanding. In this issue of Cell, Ambrogio and colleagues connect the ability of K-Ras to dimerize to the ability of wild-type K-Ras to limit the oncogenic properties of the mutant.
K-Ras 是癌基因领域当之无愧的王者，但由于我们对其致癌功能的机制理解不足，因此难以对其进行干预。在本期《细胞》杂志中，Ambrogio 及其同事将 K-Ras 的二聚化能力与野生型 K-Ras 限制突变型 K-Ras 致癌特性的能力联系起来。
Zotero 插件