Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, 2720 S Moody Ave., Portland, OR 97201, USA.
Program in Quantitative and Systems Biology, Department of Biomedical Engineering, Oregon Health & Science University, 2730 S Moody Ave., Portland, OR 97201, USA.
Genes (Basel). 2022 Jan 25;13(2):219. doi: 10.3390/genes13020219.
Formation of Ras multimers, including dimers and nanoclusters, has emerged as an exciting, new front of research in the 'old' field of Ras biomedicine. With significant advances made in the past few years, we are beginning to understand the structure of Ras multimers and, albeit preliminary, mechanisms that regulate their formation in vitro and in cells. Here we aim to synthesize the knowledge accrued thus far on Ras multimers, particularly the presence of multiple globular (G-) domain interfaces, and discuss how membrane nanodomain composition and structure would influence Ras multimer formation. We end with some general thoughts on the potential implications of Ras multimers in basic and translational biology.
Ras 多聚体（包括二聚体和纳米簇）的形成，已经成为 Ras 生物医学这一“古老”领域中令人兴奋的新研究前沿。在过去几年中取得了重大进展，我们开始了解 Ras 多聚体的结构，尽管还处于初步阶段，但已经了解了体外和细胞内调节其形成的机制。在这里，我们旨在综合迄今为止关于 Ras 多聚体的知识，特别是多个球状（G-）结构域界面的存在，并讨论膜纳米区组成和结构如何影响 Ras 多聚体的形成。最后，我们对 Ras 多聚体在基础和转化生物学中的潜在影响提出了一些一般性的思考。
